Evidence map›Paper›PMID 38921775›Full record

ArticlePathogens (Basel, Switzerland)2024

Evaluation of the Local and Peripheral Immune Responses in Patients with Cystic Echinococcosis.

Linda Petrone, Saeid Najafi-Fard, Laura Falasca, Settimia Sbarra, Antonella Teggi, Emanuele Nicastri, Lucia Rosalba Grillo, Mirco Burocchi, Giuseppe Maria Ettorre, Alessandra Ludovisi and 3 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Linda PetroneTranslational Research Unit, National Institute for Infectious Diseases (INMI) "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.
Saeid Najafi-FardTranslational Research Unit, National Institute for Infectious Diseases (INMI) "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-9957-8934
Laura FalascaLaboratory of Electron Microscopy, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8752-2415
Settimia SbarraTranslational Research Unit, National Institute for Infectious Diseases (INMI) "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.
Antonella TeggiDepartment of Infectious and Tropical Diseases, Sant'Andrea Hospital University of Rome "Sapienza", 00189 Rome, Italy.
Emanuele NicastriClinical Division of Infectious Diseases, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0002-5606-8712
Lucia Rosalba GrilloAnatomic Pathology Unit, San Camillo-Forlanini Hospital, 00152 Rome, Italy.
Mirco BurocchiDivision of General Surgery and Liver Transplantation, San Camillo-Forlanini Hospital, 00152 Rome, Italy.
Giuseppe Maria EttorreDivision of General Surgery and Liver Transplantation, San Camillo-Forlanini Hospital, 00152 Rome, Italy.
Alessandra LudovisiFoodborne and Neglected Parasitoses Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Daniele ColomboPathology Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Roma, Italy.
Franca Del NonnoPathology Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Roma, Italy.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases (INMI) "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8360-4376

Funding

Ministero della Salute GR-2016-02361497Ministero della Salute Linea 1-Ricerca Corrente
6 · The paper itself

Abstract

backgroundCystic echinococcosis (CE) cysts may persist for decades because of immune modulation mechanisms. Here, we characterize the cysts and the blood immune responses in patients with CE.

methodsWe enrolled 61 patients with CE and 19 control subjects. We received tissue samples from seven patients with CE and a control subject requiring liver cystectomy. The immunohistochemistry evaluation of the immune cell subtypes and cytokines in the pericysts and surrounding liver and the antigen B (AgB)-specific response analysis of whole blood were performed.

resultsIn CE, the pericyst and the surrounding liver parenchyma showed aggregates of CD3

conclusionIn patients with CE, CD4

Indexed as

CytokinesEchinococcosisLiverAdultAgedB-LymphocytesCD4-Positive T-LymphocytesFemaleHumansInterferon-gammaInterleukin-4MaleMiddle AgedYoung AdultCytokinesInterferon-gammaInterleukin-4cystic echinococcosiscystsIL-4immune responseimmunohistochemistry

Identifiers

PMID38921775
PMCPMC11206897

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.