Evidence map›Paper›PMID 38924296›Full record

SynthesisJournal of the International AIDS Society2024

Intervention strategies to improve adherence to treatment for selected chronic conditions in sub-Saharan Africa: a systematic review.

Siphamandla Bonga Gumede, John B F de Wit, Willem D F Venter, Annemarie M J Wensing, Samanta Tresha Lalla-Edward

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the International AIDS Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siphamandla Bonga GumedeEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-7870-1363
John B F de WitDepartment of Interdisciplinary Social Science, Utrecht University, Utrecht, the Netherlands.
Willem D F VenterEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Annemarie M J WensingDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0003-3790-8891
Samanta Tresha Lalla-EdwardEzintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Funding

Integrating HIV and hEART health in South Africa (iHeart-SA)UH3HL156388 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI ALI, MOHAMMED KUMAIL, MARCONI, VINCENT CHARLES · 2022 to 2024
$3.2M
Integrating HIV and hEART health in South Africa (iHeart-SA)UG3HL156388 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI ALI, MOHAMMED KUMAIL, MARCONI, VINCENT CHARLES · 2020 to 2021
$1.7M
Carnegie Corporation of New York G-19-57145Developing Excellence in Leadership, Training and Science in AfricaNational Heart, Lung, and Blood Institute of the National Institutes of Health UG3HL156388NHLBI NIH HHS UH3 HL156388Sida 54100113UK Foreign, Commonwealth & Development OfficeUppsala Monitoring Center, Norwegian Agency for Development CooperationUtrecht University, Department of Interdisciplinary Social Science, the NetherlandsWellcome Trust 107768/Z/15/Z
6 · The paper itself

Abstract

introductionEvidence-based intervention strategies to improve adherence among individuals living with chronic conditions are critical in ensuring better outcomes. In this systematic review, we assessed the impact of interventions that aimed to promote adherence to treatment for chronic conditions.

methodsWe systematically searched PubMed, Web of Science, Scopus, Google Scholar and CINAHL databases to identify relevant studies published between the years 2000 and 2023 and used the QUIPS assessment tool to assess the quality and risk of bias of each study. We extracted data from eligible studies for study characteristics and description of interventions for the study populations of interest.

resultsOf the 32,698 total studies/records screened, 2814 were eligible for abstract screening and of those, 497 were eligible for full-text screening. A total of 82 studies were subsequently included, describing a total of 58,043 patients. Of the total included studies, 58 (70.7%) were related to antiretroviral therapy for HIV, 6 (7.3%) were anti-hypertensive medication-related, 12 (14.6%) were anti-diabetic medication-related and 6 (7.3%) focused on medication for more than one condition. A total of 54/82 (65.9%) reported improved adherence based on the described study outcomes, 13/82 (15.9%) did not have clear results or defined outcomes, while 15/82 (18.3%) reported no significant difference between studied groups. The 82 publications described 98 unique interventions (some studies described more than one intervention). Among these intervention strategies, 13 (13.3%) were multifaceted (4/13 [30.8%] multi-component health services- and community-based programmes, 6/13 [46.2%] included individual plus group counselling and 3/13 [23.1%] included SMS or alarm reminders plus individual counselling). DISCUSSION: The interventions described in this review ranged from adherence counselling to more complex interventions such as mobile health (mhealth) interventions. Combined interventions comprised of different components may be more effective than using a single component in isolation. However, the complexity involved in designing and implementing combined interventions often complicates the practicalities of such interventions.

conclusionsThere is substantial evidence that community- and home-based interventions, digital health interventions and adherence counselling interventions can improve adherence to medication for chronic conditions. Future research should answer if existing interventions can be used to develop less complicated multifaceted adherence intervention strategies.

Indexed as

Drug MonitoringAfrica South of the SaharaChronic DiseaseHIV InfectionsHumansadherenceAfricaanti‐diabetic medicationanti‐hypertensive medicationantiretroviral therapysystematic review

Identifiers

PMID38924296
PMCPMC11197966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.