Evidence map›Paper›PMID 38924492›Full record

ArticleJournal of medicinal chemistry2024

Oxygen-Dependent Interactions between the Ruthenium Cage and the Photoreleased Inhibitor in NAMPT-Targeted Photoactivated Chemotherapy.

Selda Abyar, Luojiao Huang, Yurii Husiev, Ludovic Bretin, Bobby Chau, Vadde Ramu, Jacob Hendricus Wildeman, Kimberley Belfor, Lukas S Wijaya, Vera E van der Noord and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Selda AbyarLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Luojiao HuangLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0001-5825-5127
Yurii HusievLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0003-3776-9844
Ludovic BretinLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-2949-0512
Bobby ChauLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Vadde RamuLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0003-0726-6920
Jacob Hendricus WildemanLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0009-0008-6375-1270
Kimberley BelforLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Lukas S WijayaLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Vera E van der NoordLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Amy C HarmsLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-2931-4295
Maxime A SieglerDepartment of Chemistry, Johns Hopkins University, 3400 N Charles St, Baltimore, Maryland 21218, United States.ORCID 0000-0003-4165-7810
Sylvia E Le DévédecLeiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.
Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, PO Box 9502, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-5810-3657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoactivated chemotherapy agents form a new branch of physically targeted anticancer agents with potentially lower systemic side effects for patients. On the other hand, limited information exists on the intracellular interactions between the photoreleased metal cage and the photoreleased anticancer inhibitor. In this work, we report a new biological study of the known photoactivated compound

Indexed as

Antineoplastic AgentsNADNicotinamide PhosphoribosyltransferaseOxygenRutheniumCell Line, TumorCytokinesEnzyme InhibitorsHumansLightAntineoplastic AgentsCytokinesEnzyme InhibitorsNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanOxygenRuthenium

Identifiers

PMID38924492
PMCPMC11247496

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.