SynthesisBiological psychiatry2024
The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.
Synthesis in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- The association between pubertal timing and diurnal cortisol activity in middle adolescence.Stress (Amsterdam, Netherlands) · 2026Article
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Longitudinal MRI reveals adolescent pituitary growth patterns linked to puberty and environmental exposures.medRxiv : the preprint server for health sciences · 2026Article
- Emotional and Behavioural Problems Including Anxiety and Depressive Symptoms Across Tanner Stages in Girls With Central Precocious Puberty: A Retrospective Clinical Study.Actas espanolas de psiquiatria · 2026Article
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- Links between hormonal and pubertal development, and adolescent females' risk for affective symptoms.Psychoneuroendocrinology · 2026Article
- Timing of Sexual Initiation in Polish Adolescents: A Multilevel Study of Individual, Family, and Contextual Determinants.Archives of sexual behavior · 2026Article
- Gender "in the wild": toward a person-specific behavioral neuroendocrinology.Biology of sex differences · 2026Review
- Changes in white matter volume and cortical thickness predict internalizing symptoms during early adolescence.Journal of psychopathology and clinical science · 2026Article
- Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis.Research (Washington, D.C.) · 2026Article
- The association between physical activity and depressive symptoms in adolescents: the serial mediating roles of school connectedness and self-control.Frontiers in public health · 2026Article
- Secular trends in age at menarche among Han Chinese females in Shanghai: a large-scale community-based study.BMC women's health · 2025Article
- Trajectory and Trend of Weight Status, Emotional Wellbeing and Sleep From Infancy to Childhood to Adolescence in Scotland: An Analysis of Growing up in Scotland Birth Cohort 1.Pediatric obesity · 2025Article
- Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence.BMC pediatrics · 2025Article
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty is a time of intense reorganization of brain structure and a high-risk period for the onset of mental health problems, with variations in pubertal timing and tempo intensifying this risk. We conducted 2 systematic reviews of articles published up to February 1, 2024, focusing on 1) the role of brain structure in the relationship between puberty and mental health, and 2) precision psychiatry research evaluating the utility of puberty in making individualized predictions of mental health outcomes in young people. The first review provides inconsistent evidence about whether and how pubertal and psychopathological processes may interact in relation to brain development. While most studies found an association between early puberty and mental health difficulties in adolescents, evidence on whether brain structure mediates this relationship is mixed. The pituitary gland was found to be associated with mental health status during this time, possibly through its central role in regulating puberty and its function in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes. In the second review, the design of studies that have explored puberty in predictive models did not allow for a quantification of its predictive power. However, when puberty was evaluated through physically observable characteristics rather than hormonal measures, it was more commonly identified as a predictor of depression, anxiety, and suicidality in adolescence. Social processes may be more relevant than biological ones to the link between puberty and mental health problems and represent an important target for educational strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.