Evidence map›Paper›PMID 38926454›Full record

ArticleScientific reports2024

Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure.

Sara Cruciani, Donatella Coradduzza, Francesca Balzano, Giuseppe Garroni, Emanuela Azara, Renzo Pala, Alessandro P Delitala, Massimo Madonia, Alessandro Tedde, Giampiero Capobianco and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sara Cruciani *Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Donatella Coradduzza *Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Francesca BalzanoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Giuseppe GarroniDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Emanuela AzaraInstitute of Biomolecular Chemistry, National Research Council, 07100, Sassari, Italy.
Renzo PalaDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Alessandro P DelitalaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Massimo MadoniaDepartment of Clinical and Experimental Medicine, Urologic Clinic, University of Sassari, Sassari, Italy.
Alessandro TeddeDepartment of Clinical and Experimental Medicine, Urologic Clinic, University of Sassari, Sassari, Italy.
Giampiero CapobiancoDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Marco PetrilloDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Cecilia AngelucciDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Ciriaco CarruDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Carlo VenturaLaboratory of Molecular Biology and Stem Cell Engineering, Istituto Nazionale Biostrutture E Biosistemi (INBB)-Eldor Lab, Via Corticella 183, 40128, Bologna, Italy. ventura.vid@gmail.com.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy. mmaioli@uniss.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche. The stem cell niche is regulated by complex interactions between multiple cell types. When transplanted in a specific area, ADSCs can secrete several immunomodulatory factors. At the same time, a tumor microenvironment can influence stem cell behavior, modulating proliferation and their ability to differentiate into a specific phenotype. Whitin this context, we exposed ADSCs to plasma samples derived from human patients diagnosed with prostate cancer (PC), or precancerous lesions (PL), or benign prostatic hyperplasia (BPH) for 4, 7 or 10 days. We then analyzed the expression of main stemness-related markers and cell-cycle regulators. We also measured cytokine production and polyamine secretion in culture medium and evaluated cell morphology and collagen production by confocal microscopy. The results obtained from this study show significant changes in the morphology of ADSCs exposed to plasma samples, especially in the presence of prostate cancer plasma, suggesting important implications in the use of ADSCs for the development of new treatments and application in regenerative medicine.

Indexed as

Prostatic HyperplasiaProstatic NeoplasmsStem CellsAdipose TissueAgedCell DifferentiationCell ProliferationCells, CulturedCytokinesHumansMaleMiddle AgedProstateCytokinesAdipose-derived stem cellsCell proliferationConditioned mediaEpigeneticsProstate plasmaStem cell nicheStemness genes

Identifiers

PMID38926454
PMCPMC11208502

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.