Evidence map›Paper›PMID 38927035›Full record

ArticleBiomolecules2024

Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase.

Simona Dedoni, Maria C Olianas, Pierluigi Onali

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simona DedoniLaboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0002-7330-2179
Maria C OlianasLaboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Pierluigi OnaliLaboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy.

Funding

Sardegna Ricerche (Italy) Progetto IBERNAT-NBL -POR Sardegna 2014-2020 CUP F21B17000730005
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a well-documented pro-oncogenic factor in different cancers, but relatively little is known on its biological activity in neuroblastoma. The LPA effects and the participation of the tyrosine kinase receptor anaplastic lymphoma kinase (ALK) in LPA mitogenic signaling were studied in human neuroblastoma cell lines. We used light microscopy and [

Indexed as

Anaplastic Lymphoma KinaseCell ProliferationLysophospholipidsNeuroblastomaSignal TransductionCarbazolesCell Line, TumorForkhead Box Protein O3HumansMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 3PhosphorylationPiperidinesalectinibALK protein, humanAnaplastic Lymphoma KinaseCarbazolesForkhead Box Protein O3FOXO3 protein, humanlysophosphatidic acidLysophospholipidsMitogen-Activated Protein Kinase 3Piperidinesanaplastic lymphoma kinasecell proliferationextracellular signal-regulated kinases 1 and 2FoxO3ahuman neuroblastoma cellslysophosphatidic acid

Identifiers

PMID38927035
PMCPMC11201523

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.