Evidence map›Paper›PMID 38927583›Full record

ReviewBiomedicines2024

Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies.

Trang T T Nguyen, Lloyd A Greene, Hayk Mnatsakanyan, Christian E Badr

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Exploiting Synthetic Lethality of PRMT5 for Precision Treatment of MTAP-Deficient Glioblastoma.International journal of translational medicine (Basel, Switzerland) · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Trang T T NguyenRonald O. Perelman Department of Dermatology, Perlmutter Cancer Center, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0001-8747-9082
Lloyd A GreeneDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Hayk MnatsakanyanDepartment of Neurology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0002-7820-8675
Christian E BadrDepartment of Neurology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0002-7212-5975

Funding

Role of ER Stress and Fatty Acid Metabolism in Glioma Stem CellsR01NS113822 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BADR, CHRISTIAN ELIAS · 2020 to 2024
$2.0M
Screening for DNA Damage Response Modulators in Glioblastoma Stem CellsR33NS117554 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BADR, CHRISTIAN ELIAS · 2022 to 2023
$743k
Translocon-regulated ER proteostasis in glioblastomaR21NS119959 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BADR, CHRISTIAN ELIAS, ISHMAEL, JANE E · 2021 to 2021
$453k
NIH/NINDS and DoD Peer Reviewed Cancer Research R01NS113822, R21NS119959, R61NS117544 and CA191075NINDS NIH HHS R01 NS113822NINDS NIH HHS R21 NS119959NINDS NIH HHS R33 NS117554
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive forms of brain tumor, characterized by a daunting prognosis with a life expectancy hovering around 12-16 months. Despite a century of relentless research, only a select few drugs have received approval for brain tumor treatment, largely due to the formidable barrier posed by the blood-brain barrier. The current standard of care involves a multifaceted approach combining surgery, irradiation, and chemotherapy. However, recurrence often occurs within months despite these interventions. The formidable challenges of drug delivery to the brain and overcoming therapeutic resistance have become focal points in the treatment of brain tumors and are deemed essential to overcoming tumor recurrence. In recent years, a promising wave of advanced treatments has emerged, offering a glimpse of hope to overcome the limitations of existing therapies. This review aims to highlight cutting-edge technologies in the current and ongoing stages of development, providing patients with valuable insights to guide their choices in brain tumor treatment.

Indexed as

artificial intelligence (AI)external beam radiation therapyfMRIgene and cell therapyglioblastoma multiformeimmunotherapytargeted therapytemozolomideTTFields

Identifiers

PMID38927583
PMCPMC11202201

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.