Evidence map›Paper›PMID 38928358›Full record

ArticleInternational journal of molecular sciences2024

Assessment of Total Antioxidant Capacity, 8-Hydroxy-2'-deoxy-guanosine, the Genetic Landscape, and Their Associations in

Mihnea-Alexandru Găman, Cristina Mambet, Ana Iulia Neagu, Coralia Bleotu, Petruta Gurban, Laura Necula, Anca Botezatu, Marius Ataman, Camelia Cristina Diaconu, Bogdan Octavian Ionescu and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mihnea-Alexandru GămanFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.ORCID 0000-0001-7133-8875
Cristina MambetFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.
Ana Iulia NeaguDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.
Coralia BleotuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.ORCID 0000-0002-9031-338X
Petruta GurbanDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.
Laura NeculaDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.
Anca BotezatuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.ORCID 0000-0002-1502-9733
Marius AtamanDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.
Camelia Cristina DiaconuFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.ORCID 0000-0001-6837-260X
Bogdan Octavian IonescuDepartment of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Alexandra Elena GhiaurDepartment of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Aurelia TaticFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.
Daniel CoriuFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.ORCID 0000-0002-7251-6079
Amelia Maria GămanDepartment of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0001-6974-2772
Carmen Cristina DiaconuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.ORCID 0000-0002-2259-1425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs), namely, polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal stem cell disorders defined by an excessive production of functionally mature and terminally differentiated myeloid cells. MPNs can transform into secondary acute myeloid leukemia (sAML/blast phase MPN) and are linked to alterations in the redox balance, i.e., elevated concentrations of reactive oxygen species and markers of oxidative stress (OS), and changes in antioxidant systems. We evaluated OS in 117 chronic phase MPNs and 21 sAML cases versus controls by measuring total antioxidant capacity (TAC) and 8-hydroxy-2'-deoxy-guanosine (8-OHdG) concentrations. TAC was higher in MPNs than controls (

Indexed as

8-Hydroxy-2'-DeoxyguanosineAntioxidantsMyeloproliferative DisordersAdultAgedAged, 80 and overBlast CrisisFemaleFusion Proteins, bcr-ablHumansMaleMiddle AgedOxidative StressPrimary Myelofibrosis8-Hydroxy-2'-DeoxyguanosineAntioxidantsFusion Proteins, bcr-abl8-hydroxy-2′-deoxy-guanosineantioxidant capacityleukemic transformationmyeloproliferative neoplasmsoxidative stressreactive oxygen speciessecondary acute myeloid leukemia

Identifiers

PMID38928358
PMCPMC11203765

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.