Evidence map›Paper›PMID 38928370›Full record

ReviewInternational journal of molecular sciences2024

Involvement of Reactive Oxygen Species in Prostate Cancer and Its Disparity in African Descendants.

Geou-Yarh Liou, Reauxqkwuanzyiia C'lay-Pettis, Sravankumar Kavuri

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. C-reactive protein-albumin-lymphocyte index predicts biochemical recurrence in prostate cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
    Article
  3. Genetic Polymorphisms and Antioxidant Reactions in Prostate Cancer.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Geou-Yarh LiouCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.ORCID 0000-0003-2728-3752
Reauxqkwuanzyiia C'lay-PettisCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.
Sravankumar KavuriDepartment of Pathology, Augusta University Health, Augusta, GA 30912, USA.

Funding

To Investigate Molecular Mechanisms of Aging-Related Growth of the Prostate - Implications in Prostate Tumorigenesis and Cancer TreatmentU54MD007590 · NIMHD · CLARK ATLANTA UNIVERSITY · PI Shafiq A Khan · 2019 to 2026
$17.1M
Dissecting mechanisms of tumor initiation via immunomodulationSC1GM140907 · NIGMS · CLARK ATLANTA UNIVERSITY · PI LIOU, GEOU-YARH · 2021 to 2024
$1.3M
AU Medical Center, Inc. CAU-AU Partnership-Kavuri-LiouNIGMS NIH HHS SC1 GM140907NIGMS NIH HHS SC1GM140907NIMHD NIH HHS U54 MD007590NIMHD NIH HHS U54MD007590PCR Inc 5001
6 · The paper itself

Abstract

Reactive oxygen species (ROS) participate in almost all disorders, including cancer. Many factors, including aging, a high-fat diet, a stressful lifestyle, smoking, infection, genetic mutations, etc., lead to elevated levels of ROS. Prostate cancer, the most prevalent type of cancer in senior American men and the second leading cause of cancer mortality in American men, results from chronic oxidative stress. The doubled incident rate as well as the doubled mortality numbers of prostate cancer have persisted in African Americans in comparison with Caucasian Americans and other racial groups, indicating a prostate cancer disparity in African American men. In this review, we mainly focus on the latest findings on ROS in prostate cancer development and progression within the last five years to update our understanding in this area, as several comprehensive literature reviews addressing oxidative stress and/or inflammation in prostate cancer before 2020 are available. In addition to other known factors such as socioeconomic disadvantage, cultural mistrust of the health care system, etc. that are long-existing in the African American group, we also summarize the latest evidence that demonstrated high systemic oxidative stress and inflammation in African Americans for their potential contribution to the racial prostate cancer disparity in this population.

Indexed as

Black or African AmericanOxidative StressProstatic NeoplasmsReactive Oxygen SpeciesBlack PeopleHealth Status DisparitiesHumansInflammationMaleReactive Oxygen SpeciesAfrican Americansinflammationoxidative stressprostate cancerracial disparityreactive oxygen species

Identifiers

PMID38928370
PMCPMC11203985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.