Evidence map›Paper›PMID 38928446›Full record

ReviewInternational journal of molecular sciences2024

Pregnant Women with Multiple Sclerosis: An Overview of Gene Expression and Molecular Interaction Using Bioinformatics Analysis.

Jazmin Marquez-Pedroza, Martha Rocio Hernández-Preciado, Edgar Ricardo Valdivia-Tangarife, Francisco J Alvarez-Padilla, Mario Alberto Mireles-Ramírez, Blanca Miriam Torres-Mendoza

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jazmin Marquez-PedrozaNeurosciences Division, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-2859-726X
Martha Rocio Hernández-PreciadoDepartment of Philosophical and Methodological Disciplines, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Mexico.ORCID 0000-0003-4757-4792
Edgar Ricardo Valdivia-TangarifeDepartment of Neurosciences, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Mexico.
Francisco J Alvarez-PadillaTranslational Bioengineering Department, University Center of Exact Sciences and Engineering, University of Guadalajara, Guadalajara 44430, Mexico.ORCID 0000-0003-0665-5895
Mario Alberto Mireles-RamírezHigh Specialty Medical Unit, Western National Medical Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0002-8321-7883
Blanca Miriam Torres-MendozaNeurosciences Division, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-2233-571X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a common disease in young women of reproductive age, characterized by demyelination of the central nervous system (CNS). Understanding how genes related to MS are expressed during pregnancy can provide insights into the potential mechanisms by which pregnancy affects the course of this disease. This review article presents evidence-based studies on these patients' gene expression patterns. In addition, it constructs interaction networks using bioinformatics tools, such as STRING and KEGG pathways, to understand the molecular role of each of these genes. Bioinformatics research identified 25 genes and 21 signaling pathways, which allows us to understand pregnancy patients' genetic and biological phenomena and formulate new questions about MS during pregnancy.

Indexed as

Computational BiologyMultiple SclerosisFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansPregnancyPregnancy ComplicationsSignal Transductionbioinformaticsgene expressionmolecular interactionmultiple sclerosispregnancy

Identifiers

PMID38928446
PMCPMC11203715

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.