Evidence mapPaperPMID 38928486Full record

ReviewInternational journal of molecular sciences2024

The Application of Clinical and Molecular Diagnostic Techniques to Identify a Rare Haemoglobin Variant.

Michela Salvatici, Cecilia Caslini, Simona Alesci, Grazia Arosio, Giuliana Meroni, Ferruccio Ceriotti, Massimiliano Ammirabile, Lorenzo Drago

Abstract readReviewCase Reports
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michela SalvaticiUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Via Fantoli 16/15, 20138 Milan, Italy.
Cecilia CasliniBianalisi, Clinical Laboratory, Via Mattavelli 3, 20841 Carate Brianza, Italy.
Simona AlesciBianalisi, Clinical Laboratory, Via Mattavelli 3, 20841 Carate Brianza, Italy.
Grazia ArosioBianalisi, Clinical Laboratory, Via Mattavelli 3, 20841 Carate Brianza, Italy.
Giuliana MeroniBianalisi, Clinical Laboratory, Via Mattavelli 3, 20841 Carate Brianza, Italy.
Ferruccio CeriottiClinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.ORCID 0000-0002-0958-5354
Massimiliano AmmirabileClinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.ORCID 0009-0008-3910-2617
Lorenzo DragoUOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica, Via Fantoli 16/15, 20138 Milan, Italy.ORCID 0000-0002-5206-540X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haemoglobin disorders represent a heterogeneous group of inherited conditions that involve at least one genetic abnormality in one or more of the globin chains, resulting in changes in the structure, function, and/or amount of haemoglobin molecules, which are very important for their related clinical aspects. Detecting and characterizing these disorders depends primarily on laboratory methods that employ traditional approaches and, when necessary, newer methodologies essential for solving a number of diagnostic challenges. This review provides an overview of key laboratory techniques in the diagnosis of haemoglobinopathies, focusing on the challenges, advancements, and future directions in this field. Moreover, many haemoglobinopathies are benign and clinically silent, but it is not uncommon to find unexpected variants during routine laboratory tests. The present work reported a rare and clinically interesting case of identification of haemoglobin fractions in an adult man by the determination of glycated haemoglobin (HbA

Indexed as

HemoglobinopathiesMolecular Diagnostic TechniquesGlycated HemoglobinHemoglobinsHemoglobins, AbnormalHumansMaleGlycated HemoglobinHemoglobinsHemoglobins, Abnormalcardiovascular riskhaemoglobinopathyHbA1claboratory techniquespulmonary hypertensionunusual case

Identifiers

PMID38928486
PMCPMC11204072

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.