Evidence map›Paper›PMID 38928503›Full record

ArticleInternational journal of molecular sciences2024

The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization.

Ke Huang, Weijia Yang, Mingxuan Shi, Shiqi Wang, Yi Li, Zhaoqing Xu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ke HuangKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730030, China.ORCID 0000-0002-8257-5558
Weijia YangKey Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou 730030, China.
Mingxuan ShiKey Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou 730030, China.ORCID 0000-0001-9161-9906
Shiqi WangKey Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou 730030, China.
Yi LiKey Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou 730030, China.
Zhaoqing XuKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730030, China.

Funding

the Cuiying Science and Technology Innovation Project of Lanzhou University Second Hospital No.CY-2023- QY-B08the Fundamental Research Funds for the Central Universities, Lanzhou University lzujbky-2023-07the Key Research and Development Program of Gansu Province, China (International Scientific and Technological Cooperation Category) No. 23YFWA0003the Natural Science Foundation of Gansu Province No.23JRRA0981the Science and Technology Planning Project of Lanzhou, China No. 2023-2-10
6 · The paper itself

Abstract

Ischemic heart disease (IHD) remains a major global health concern, with ischemia-reperfusion injury exacerbating myocardial damage despite therapeutic interventions. In this study, we investigated the role of tropomyosin 3 (TPM3) in protecting cardiomyocytes against hypoxia-induced injury and oxidative stress. Using the AC16 and H9c2 cell lines, we established a chemical hypoxia model by treating cells with cobalt chloride (CoCl

Indexed as

Cell HypoxiaCytoskeletonMyocytes, CardiacOxidative StressTropomyosinAnimalsCell LineCobaltHypoxia-Inducible Factor 1, alpha SubunitRatsCobaltcobaltous chlorideHypoxia-Inducible Factor 1, alpha SubunitTPM3 protein, humanTropomyosincardiomyocyte injurycytoskeletonhypoxiaoxidative stressTPM3

Identifiers

PMID38928503
PMCPMC11203979

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.