Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.

Zehua Liu, Jianshen Liu, Ruoxin Tang, Zhaowan Zhang, Shuangqi Tian

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Insights on the Health Benefits and Functional Potential of Food Bioactive Compounds.Foods (Basel, Switzerland) · 2025
Article
The impact of supplementation with highland barley in different nutrients on weight loss: The nutrients and function relationship.Food chemistry: X · 2025
Article
Malícia honey (Frontiers in nutrition · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zehua LiuGrain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration/Key Laboratory of Henan Province, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Jianshen LiuGrain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration/Key Laboratory of Henan Province, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Ruoxin TangGrain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration/Key Laboratory of Henan Province, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Zhaowan ZhangGrain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration/Key Laboratory of Henan Province, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Shuangqi TianGrain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration/Key Laboratory of Henan Province, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Funding

Grain, Oil and Food Engineering Technology Research Center of the State Grain and Reserves Administration /Key Laboratory of Henan Province, Henan University of Technology GO202210High-Level Talent Research Start-up Fund Project of Henan University of Technology 2022BS008Major Science and Technology Project of Henan 231100110300National Natural Science Foundation of China 32202027

6 · The paper itself

Abstract

A whole-grain highland barley (WHB) diet has been recognized to exhibit the potential for alleviating hyperlipidemia, which is mainly characterized by lipids accumulation in the serum and liver. Previously, procyanidin B1 (PB) and coumaric acid (CA) from WHB were found to alleviate serum lipid accumulation in impaired glucose tolerance mice, while the effect on modulating the hepatic lipid metabolism remains unknown. In this study, the results showed the supplementation of PB and CA activated the expression of peroxisome proliferator-activated receptor α (PPARα) and the target genes of cholesterol 7-α hydroxylase (

Indexed as

coumaric aciddiabetesgut microbiota dysbiosishigh-fat diethyperlipidemiaprocyanidin B1whole-grain highland barley

Identifiers

PMID38928784

DOI10.3390/foods13121843

PMCPMC11202444

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.