ReviewJournal of clinical medicine2024
Acute Kidney Injury in Neonatal Intensive Care Unit: Epidemiology, Diagnosis and Risk Factors.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global prevalence of acute kidney injury (AKI) in preterm neonates: an epidemiological meta-analysis.European journal of pediatrics · 2026Pooled it
- Incidence and risk factors of vancomycin-associated nephrotoxicity among neonates in the intensive care unit: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Early postnatal changes in serum creatinine from birth to peak and subsequent decline in preterm neonates.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal acute kidney injury: where are we now?Pediatric nephrology (Berlin, Germany) · 2026Review
- The early predictive value of Cys-C, lactic acid, and urinary microglobulins in acute kidney injury following neonatal asphyxia.Translational pediatrics · 2026Article
- The '72-Hour Divergence' in severe hyperbilirubinemia: sepsis is associated with altered renal and hematologic adaptation in a 10-year exchange transfusion cohort.BMC pediatrics · 2026Article
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Renal resistive index and neonatal sequential organ failure assessment score as acute kidney injury risk predictors in preterm neonates with late-onset neonatal sepsis.Frontiers in nephrology · 2026Article
- The role of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in detecting acute kidney injury in preterm neonates exposed to nephrotoxic drugs.BMC pediatrics · 2025Observational
- Urinary KIM-1 for Early Detection of Acute Kidney Injury in Neonates: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Evaluation of acute kidney injury in preterm infants using serum creatinine decline in comparison with KDIGO criteria.Pediatric nephrology (Berlin, Germany) · 2025Article
- The diagnostic value of angiotensin, g-GT, blood lactate, and renal resistance index combined detection in acute kidney injury after neonatal asphyxia.Journal of medical biochemistry · 2025Article
- Evaluation of risk factors and outcomes of neonates with hypoxic ischemic encephalopathy and acute kidney injury.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Acute Kidney Injury in the Neonatal Period: Retrospective Data and Implications for Clinical Practice.Children (Basel, Switzerland) · 2025Article
- Pediatric Chronic Kidney Disease: Mind the Gap Between Reality and Expectations.Children (Basel, Switzerland) · 2025Review
- Review of Precision Medicine and Diagnosis of Neonatal Illness.Diagnostics (Basel, Switzerland) · 2025Review
- Preterm Birth and Kidney Health: From the Womb to the Rest of Life.Children (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is associated with long-term consequences and poor outcomes in the neonatal intensive care unit. Its precocious diagnosis represents one of the hardest challenges in clinical practice due to the lack of sensitive and specific biomarkers. Currently, neonatal AKI is defined with urinary markers and serum creatinine (sCr), with limitations in early detection and individual treatment. Biomarkers and risk factor scores were studied to predict neonatal AKI, to early identify the stage of injury and not the damage and to anticipate late increases in sCr levels, which occurred when the renal function already began to decline. Sepsis is the leading cause of AKI, and sepsis-related AKI is one of the main causes of high mortality. Moreover, preterm neonates, as well as patients with post-neonatal asphyxia or after cardiac surgery, are at a high risk for AKI. Critical patients are frequently exposed to nephrotoxic medications, representing a potentially preventable cause of AKI. This review highlights the definition of neonatal AKI, its diagnosis and new biomarkers available in clinical practice and in the near future. We analyze the risk factors involving patients with AKI, their outcomes and the risk for the transition from acute damage to chronic kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.