Evidence map›Paper›PMID 38933774›Full record

ArticleFundamental research2023

Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception of

Wenli Wang, Dingqiang Lu, Qiuda Xu, Yulian Jin, Guangchang Pang, Yuan Liu

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In one paragraph

Article in Fundamental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenli WangDepartment of Food Science & Technology, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Dingqiang LuCollege of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China.
Qiuda XuCollege of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China.
Yulian JinCollege of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China.
Guangchang PangCollege of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China.
Yuan LiuDepartment of Food Science & Technology, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sweet and umami tastes are elicited by sweet and umami receptors on the tongue and palate epithelium, respectively. However, the molecular machinery allowing the taste reaction remains incompletely understood. Through a phosphoproteomic approach, we identified the key proteins that trigger taste mechanisms based on phosphorylation cascades. Ryanodine receptor isoform 1 (RYR1) was further verified by sensory and behavioral assays. We propose a model of RYR1-mediated sweet/umami signaling in which the RYR1 channel, which mediates Ca

Indexed as

Metabolic clockPhosphoproteomicRyanodine receptor isoform 1SweetUmami

Identifiers

PMID38933774
PMCPMC11197482

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.