Evidence map›Paper›PMID 38933816›Full record

ArticleFrontiers in neuroscience2024

Tractometry of the Human Connectome Project: resources and insights.

John Kruper, McKenzie P Hagen, François Rheault, Isaac Crane, Asa Gilmore, Manjari Narayan, Keshav Motwani, Eardi Lila, Chris Rorden, Jason D Yeatman and 1 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Neonatal brain-age models in full- and preterm infants.Developmental cognitive neuroscience · 2026
    Article
  3. Review
  4. Two axes of white matter development.Nature communications · 2026
    Article
  5. Neonatal brain-age models in full- and preterm infants.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. If Freud had known….Frontiers in psychology · 2025
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John KruperDepartment of Psychology, University of Washington, Seattle, WA, United States.
McKenzie P HagenDepartment of Psychology, University of Washington, Seattle, WA, United States.
François RheaultDepartment of Computer Science, Universitè de Sherbrooke, Sherbrooke, QC, Canada.
Isaac CraneDepartment of Psychology, University of Chicago, Chicago, IL, United States.
Asa GilmoreDepartment of Psychology, University of Washington, Seattle, WA, United States.
Manjari NarayanGraduate School of Education, Stanford University, Stanford, CA, United States.
Keshav MotwaniDepartment of Biostatistics, University of Washington, Seattle, WA, United States.
Eardi LilaDepartment of Biostatistics, University of Washington, Seattle, WA, United States.
Chris RordenDepartment of Psychology, University of South Carolina, Columbia, SC, United States.
Jason D YeatmanGraduate School of Education, Stanford University, Stanford, CA, United States.
Ariel RokemDepartment of Psychology, University of Washington, Seattle, WA, United States.

Funding

CRCNS: Community-supported open-source software for computational neuroanatomyR01EB027585 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI Eleftherios Garyfallidis · 2018 to 2026
$2.6M
Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualizationRF1MH133701 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RORDEN, CHRISTOPHER · 2023 to 2023
$2.0M
A data science toolbox for analysis of Human Connectome Project diffusion MRIRF1MH121868 · NIMH · UNIVERSITY OF WASHINGTON · PI ROKEM, ARIEL SHALOM · 2019 to 2019
$707k
Statistical models for the integrative analysis of complex biomedical images with manifold structureR03EB033001 · NIBIB · UNIVERSITY OF WASHINGTON · PI LILA, EARDI · 2023 to 2024
$151k
NIBIB NIH HHS R01 EB027585NIBIB NIH HHS R03 EB033001NIMH NIH HHS RF1 MH121868NIMH NIH HHS RF1 MH133701
6 · The paper itself

Abstract

Introduction: The Human Connectome Project (HCP) has become a keystone dataset in human neuroscience, with a plethora of important applications in advancing brain imaging methods and an understanding of the human brain. We focused on tractometry of HCP diffusion-weighted MRI (dMRI) data. Methods: We used an open-source software library (pyAFQ; https://yeatmanlab.github.io/pyAFQ) to perform probabilistic tractography and delineate the major white matter pathways in the HCP subjects that have a complete dMRI acquisition ( Results: We released the processing outputs and tract profiles as a publicly available data resource through the AWS Open Data program's Open Neurodata repository. We found heritability as high as 0.9 for DKI-based metrics in some brain pathways. We also found that tractometry extracts as much useful information about individual differences as the local connectome method. We released a new web-based visualization tool for tractometry-"Tractoscope" (https://nrdg.github.io/tractoscope). We found that the TRX files require considerably less disk space-a crucial attribute for large datasets like HCP. In addition, TRX incorporates a specification for grouping streamlines, further simplifying tractometry analysis.

Indexed as

braindata visualizationdiffusion MRIheritabilityMRIOpen Datapredictive modelingtractometry

Identifiers

PMID38933816
PMCPMC11199395

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.