ArticleSleep2024
The interplay between insomnia symptoms and Alzheimer's disease across three main brain networks.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sleep Fragmentation and Sleep Stages 1 and 2 Are Associated With Amyloid-Beta Burden in Cognitively Normal Older Adults.Journal of sleep research · 2026Trial
- Elevating sleep to a global health priority: The One Sleep Health framework.Cell reports. Medicine · 2026Review
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Multimodal integration of neuroimaging, transcriptomics and single-cell analysis reveals molecular correlates linking osteoporosis to brain abnormalities.Frontiers in immunology · 2026Article
- Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-Frontiers in neuroscience · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Prefrontal cortex hypoactivation in response to sleep-related pictures in shift workers.Brain structure & function · 2025Article
- Association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline: a prospective cohort study.Age and ageing · 2025Article
- Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.Nature. Mental health · 2025Article
- Article
- Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study.BMJ open ophthalmology · 2025Article
- Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults.Frontiers in aging neuroscience · 2025Article
- Association between perfluoroalkyl and polyfluoroalkyl substances and adolescents' sleep disorders: NHANES 2005-2018.Frontiers in nutrition · 2025Article
- Acupuncture for chronic insomnia with mild cognitive impairment: protocol for a randomized controlled trial.Frontiers in neurologyArticle
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Abstract
STUDY
objectivesInsomnia symptoms are prevalent along the trajectory of Alzheimer's disease (AD), but the neurobiological underpinning of their interaction is poorly understood. Here, we assessed structural and functional brain measures within and between the default mode network (DMN), salience network, and central executive network (CEN).
methodsWe selected 320 participants from the ADNI database and divided them by their diagnosis: cognitively normal (CN), Mild Cognitive Impairment (MCI), and AD, with and without self-reported insomnia symptoms. We measured the gray matter volume (GMV), structural covariance (SC), degrees centrality (DC), and functional connectivity (FC), testing the effect and interaction of insomnia symptoms and diagnosis on each index. Subsequently, we performed a within-group linear regression across each network and ROI. Finally, we correlated observed abnormalities with changes in cognitive and affective scores.
resultsInsomnia symptoms were associated with FC alterations across all groups. The AD group also demonstrated an interaction between insomnia and diagnosis. Within-group analyses revealed that in CN and MCI, insomnia symptoms were characterized by within-network hyperconnectivity, while in AD, within- and between-network hypoconnectivity was ubiquitous. SC and GMV alterations were nonsignificant in the presence of insomnia symptoms, and DC indices only showed network-level alterations in the CEN of AD individuals. Abnormal FC within and between DMN and CEN hubs was additionally associated with reduced cognitive function across all groups, and increased depressive symptoms in AD.
conclusionsWe conclude that patients with clinical AD present with a unique pattern of insomnia-related functional alterations, highlighting the profound interaction between both conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.