Evidence map›Paper›PMID 38935868›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations.

Robin Lu, Andrew Gregory, Rahul Suryadevara, Zhonghui Xu, Dhawal Jain, Jarrett D Morrow, Brian D Hobbs, Jeong H Yun, Noah Lichtblau, Robert Chase and 8 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Lung NR3C1Communications biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Robin LuChanning Division of Network Medicine.
Andrew GregoryChanning Division of Network Medicine.
Rahul SuryadevaraChanning Division of Network Medicine.ORCID 0000-0002-3182-0250
Zhonghui XuChanning Division of Network Medicine.
Dhawal JainChanning Division of Network Medicine.
Jarrett D MorrowChanning Division of Network Medicine.ORCID 0000-0002-5670-5865
Brian D HobbsChanning Division of Network Medicine.ORCID 0000-0001-9564-0745
Jeong H YunChanning Division of Network Medicine.ORCID 0000-0002-4361-8295
Noah LichtblauChanning Division of Network Medicine.
Robert ChaseChanning Division of Network Medicine.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan.ORCID 0000-0001-5191-4847
Maor SaulerPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut; and.
Brian J BartholmaiDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Edwin K SilvermanChanning Division of Network Medicine.
Craig P HershChanning Division of Network Medicine.ORCID 0000-0002-1342-4334
Peter J CastaldiChanning Division of Network Medicine.
Adel BoueizChanning Division of Network Medicine.ORCID 0000-0003-1638-8575
COPDGene Investigators

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SILVERMAN, EDWIN K · 2013 to 2025
$24.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
COPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2M
Imaging and multi-omics analyses to identify molecular subtypes of distinct emphysema patternsR01HL167072 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Adel El Boueiz · 2023 to 2026
$3.4M
Prospective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5M
Integrative 'Omics of Transcriptome Complexity in COPDK01HL157613 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAFERALI, AABIDA · 2021 to 2025
$944k
The role of COPD genetic risk factor HHIP on lymphocytic inflammationK08HL146972 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI YUN, JEONG H · 2020 to 2024
$848k
Alpha-1 FoundationCOPD FoundationNHLBI NIH HHSNHLBI NIH HHS K01 HL157613NHLBI NIH HHS K08 HL146972NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01 HL147326NHLBI NIH HHS R01 HL167072NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897TOPMed Fellowship
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

LungMacrophagesPulmonary EmphysemaTranscriptomeAgedFemaleGene Expression ProfilingHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSequence Analysis, RNAemphysemaimaginginflammationpathwaystranscriptomics

Identifiers

PMID38935868
PMCPMC11755365

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.