Tracking DOT1L methyltransferase activity by stable isotope labelling using a selective synthetic co-factor.

Nicole Trainor, Harry J Whitwell, Beatriz Jiménez, Katie Addison, Emily Leonidou, Peter A DiMaggio, Matthew J Fuchter

Abstract read

In one paragraph

Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Covalent chemical probes.Communications chemistry · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicole Trainor *Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 OBZ, UK.ORCID http://orcid.org/0000-0002-3758-9969

Harry J Whitwell *National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, IRDB, Building Imperial College London, London, W12 ONN, UK.

Beatriz JiménezNational Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, IRDB, Building Imperial College London, London, W12 ONN, UK.

Katie AddisonDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 OBZ, UK.

Emily LeonidouDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 OBZ, UK.

Peter A DiMaggioDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

Matthew J FuchterDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 OBZ, UK. m.fuchter@imperial.ac.uk.ORCID http://orcid.org/0000-0002-1767-7072

Funding

Cancer Research UK 23619Cancer Research UK (CRUK) C33325/A236190Cancer Research UK (CRUK) EDDCPJT\100022RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/R00188X/1RCUK | MRC | Medical Research Foundation MR.R02524X/1

6 · The paper itself

Abstract

Epigenetic processes influence health and disease through mechanisms which alter gene expression. In contrast to genetic changes which affect DNA sequences, epigenetic marks include DNA base modifications or post-translational modification (PTM) of proteins. Histone methylation is a prominent and versatile example of an epigenetic marker: gene expression or silencing is dependent on the location and extent of the methylation. Protein methyltransferases exhibit functional redundancy and broad preferences for multiple histone residues, which presents a challenge for the study of their individual activities. We developed an isotopically labelled analogue of co-factor S-adenosyl-L-methionine (

Identifiers

PMID38937590

DOI10.1038/s42004-024-01227-x

PMCPMC11211345

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.