ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- A two-system theory of sensory-evoked brain responses.Brain : a journal of neurology · 2026Review
- Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques.Neuroscience bulletin · 2026Article
- Thalamic burst and tonic firing selectively indicate patients' consciousness level and recovery.Innovation (Cambridge (Mass.)) · 2025Article
- [Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Long-range thalamocortical communication is central to anesthesia-induced loss of consciousness and its reversal. However, isolating the specific neural networks connecting thalamic nuclei with various cortical regions for state-specific anesthesia regulation is challenging, with the biological underpinnings still largely unknown. Here, simultaneous electroencephalogram-fuctional magnetic resonance imaging (EEG-fMRI) and deep brain stimulation are applied to the intralaminar thalamus in macaques under finely-tuned propofol anesthesia. This approach led to the identification of an intralaminar-driven network responsible for rapid arousal during slow-wave oscillations. A network-based RNA-sequencing analysis is conducted of region-, layer-, and cell-specific gene expression data from independent transcriptomic atlases and identifies 2489 genes preferentially expressed within this arousal network, notably enriched in potassium channels and excitatory, parvalbumin-expressing neurons, and oligodendrocytes. Comparison with human RNA-sequencing data highlights conserved molecular and cellular architectures that enable the matching of homologous genes, protein interactions, and cell types across primates, providing novel insight into network-focused transcriptional signatures of arousal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.