Evidence mapPaperPMID 38938250Full record

ArticleJACC. Advances2023

Single Ventricular Torsional Mechanics After Fontan Palliation and Their Impact on Outcomes.

Addison Gearhart, Sunakshi Bassi, David Liddle, Nikhil Thatte, Jamie K Harrington, Rahul H Rathod, Sunil J Ghelani

Abstract read
In one paragraph

Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Ventricular dyssynchrony late after the Fontan operation is associated with decreased survival.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Addison GearhartDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Sunakshi BassiDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
David LiddleDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Nikhil ThatteDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Jamie K HarringtonDepartment of Cardiology, Columbia University Irving Medical Center, New York City, New York, USA.
Rahul H RathodDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Sunil J GhelaniDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · CHILDREN'S HOSPITAL BOSTON · 1985 to 2025
$2.7M
NHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

Background: Abnormal left ventricular (LV) rotational mechanics in biventricular hearts are associated with adverse outcomes; however, these are less well characterized for hearts with functionally single ventricles. Objectives: The purpose of this study was to characterize ventricular rotational mechanics in the Fontan circulation and their relationship to outcomes. Methods: Single-center, retrospective analysis of magnetic resonance examinations for 329 Fontan patients (15 [IQR: 10-21] years) and 42 controls. The ventricular cine short-axis stack was analyzed to derive torsion metrics. Torsion calculated as the difference between apical and basal rotation normalized to ventricular length. Results: Fontan patients had higher indexed ventricular end-diastolic volume (97 mL/body surface area Conclusions: Single ventricles in a Fontan circulation exhibit abnormal torsional mechanics, which are more pronounced for RV morphology. Abnormal torsion is associated with death or need for heart transplantation. Fontan patients with LV morphology and preserved torsion exhibit the highest transplant-free survival and torsion may offer incremental prognostic data in this group of patients.

Indexed as

cardiac magnetic resonance imagingcongenital heart diseaseFontan palliationtorsionventricular mechanics

Identifiers

PMID38938250
PMCPMC11198362

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.