Evidence map›Paper›PMID 38939405›Full record

ArticleJACC. Advances2024

Associations Between Cardiac Function and Brain Health in Diverse Middle-Aged Adults: The Dallas Heart Study-2.

John M Giacona, Ricardo Chia, Weerapat Kositanurit, Jijia Wang, Colby Ayers, Ambarish Pandey, Julia Kozlitina, Mark H Drazner, Sonia Garg, James A de Lemos and 5 more

Abstract read
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Left ventricular remodeling and diastolic dysfunction predict cognitive decline in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

John M GiaconaHypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ricardo ChiaHypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Weerapat KositanuritHypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jijia WangDepartment of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Colby AyersCardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ambarish PandeyCardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Julia KozlitinaEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mark H DraznerCardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sonia GargCardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
James A de LemosCardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Rong ZhangDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ihab HajjarDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Frank F YuDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Laura LacritzDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Wanpen VongpatanasinHypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

Background: Previous studies have linked cardiovascular risk factors during midlife to cognitive function in later life. However, few studies have looked at the association between cardiac function, brain structure, and cognitive function and even less have included diverse middle-aged populations. Objectives: The objective of this study was to determine associations between cardiac and brain structure and function in a multiethnic cohort of middle-aged adults. Methods: A cross-sectional study was conducted in participants of the Dallas Heart Study phase 2 (N = 1,919; 46% Black participants). Left ventricular (LV) mass, LV ejection fraction, LV concentricity, and peak systolic strain (LV E Results: LV ejection fraction was associated with total Montreal Cognitive Assessment score (β = 0.06 [95% CI: 0.003-0.12], Conclusions: Subclinical cardiac dysfunction indicated by LVEF was associated with lower cognitive function. Moreover, LV mass and concentric remodeling were associated with higher WMH burden, particularly among Black individuals.

Indexed as

Alzheimer diseasecardiac functioncardiac structurecognitive functiondementiarace

Identifiers

PMID38939405
PMCPMC11198548

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.