Evidence map›Paper›PMID 38940423›Full record

ArticleBioanalysis2024

A hybrid IA-LC-MS/MS method for adrenocorticotropic hormone(1-24) to support interpretation of low-dose cosyntropin-stimulation test.

Barry R Jones, Junlong Shao, Mitesh Sanghvi, Alejandro Ayala, Rosa Luo, Jian Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioanalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barry R JonesCrinetics Pharmaceuticals, 6055 Lusk Blvd, San Diego, CA 92121, USA.
Junlong ShaoPharmaron (Germantown) Lab Services, Inc., 20340 Seneca Meadows Parkway, Germantown, MD 20876, USA.
Mitesh SanghviPharmaron (Germantown) Lab Services, Inc., 20340 Seneca Meadows Parkway, Germantown, MD 20876, USA.
Alejandro AyalaCrinetics Pharmaceuticals, 6055 Lusk Blvd, San Diego, CA 92121, USA.ORCID 0000-0002-2298-6769
Rosa LuoCrinetics Pharmaceuticals, 6055 Lusk Blvd, San Diego, CA 92121, USA.
Jian WangCrinetics Pharmaceuticals, 6055 Lusk Blvd, San Diego, CA 92121, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenocorticotropic hormone 1-24 (ACTH[1-24]) has a similar effect as endogenous ACTH(1-39) to generate cortisol by targeting the MC2R receptor on the adrenal gland. A new investigational ACTH receptor antagonist drug is being developed to treat diseases of ACTH excess (e.g., Cushing's disease) by binding to the MC2R receptor. Administration of ACTH(1-24) was used in a Phase I clinical study to assess the ability of this drug candidate to suppress the cortisol response to ACTH stimulation. A hybrid immunoaffinity-LCMS assay measuring ACTH(1-24) with a concentration range of 10 to 400 pg/ml was developed to support the study. Consistent and acceptable A&P results were achieved. The assay development and qualification will be discussed.

Indexed as

Adrenocorticotropic HormoneCosyntropinTandem Mass SpectrometryChromatography, LiquidHumansHydrocortisoneLiquid Chromatography-Mass SpectrometryAdrenocorticotropic HormoneCosyntropinHydrocortisoneACTH(1–24)ACTH(1–39)bead conjugationcosyntropin-stimulation test (CST)fit-for-purposehybrid IA-LC-MS

Identifiers

PMID38940423
PMCPMC11389734

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.