Evidence map›Paper›PMID 38940434›Full record

ArticleJournal of toxicology and environmental health. Part A2024

Enhancement of keratinocyte survival and migration elicited by interleukin 24 upregulation in dermal microvascular endothelium upon welding-fume exposure.

Maori Kono, Nami Ishihara, Tatsuto Nakane, Yu Nabetani, Mizuo Kajino, Tomoaki Okuda, Masahiko Hayashi, Chihaya Koriyama, Christoph F A Vogel, Mayumi Tsuji and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology and environmental health. Part A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maori KonoLaboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Nami IshiharaProgram of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Tatsuto NakaneProgram of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Yu NabetaniDepartment of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, Japan.
Mizuo KajinoMeteorological Research Institute, Japan Meteorological Agency, Tsukuba, Ibaraki, Japan.
Tomoaki OkudaFaculty of Science and Technology, Keio University, Tokyo, Kanagawa, Japan.
Masahiko HayashiFaculty of Science, Fukuoka University, Fukuoka, Japan.
Chihaya KoriyamaDepartment of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Christoph F A VogelDepartment of Environmental Toxicology, University of California, Davis, CA, USA.
Mayumi TsujiDepartment of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
Yasuhiro IshiharaProgram of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.

Funding

Air pollution, atherosclerosis, and the role of the aryl hydrocarbon receptorR01ES029126 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VOGEL, CHRISTOPH F A · 2019 to 2023
$1.8M
The impact of Aryl hydrocarbon receptor signaling on Toll like receptor-mediated inflammationR01ES032827 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHRISTOPH F A VOGEL · 2022 to 2026
$1.7M
NIEHS NIH HHS R01 ES029126NIEHS NIH HHS R01 ES032827
6 · The paper itself

Abstract

Occupational exposure to welding fumes constitutes a serious health concern. Although the effects of fumes on the respiratory tract have been investigated, few apparent reports were published on their effects on the skin. The purpose of this study was to investigate the effects of exposure to welding fumes on skin cells, focusing on interleukin-24 (IL-24), a cytokine involved in the pathophysiology of skin conditions, such as atopic dermatitis and psoriasis. Treatment with welding fumes increased IL-24 expression and production levels in human dermal microvascular endothelial cells (HDMEC) which were higher than that in normal human epidermal keratinocytes. IL-24 levels in Trolox and deferoxamine markedly suppressed welding fume-induced IL-24 expression in HDMEC, indicating that oxidative stress may be involved in this cytokine expression. IL-24 released from HDMEC protected keratinocytes from welding fume-induced damage and enhanced keratinocyte migration. Serum IL-24 was higher in welding workers than in general subjects and was positively correlated with elevated serum levels of 8-hydroxy-2'-deoxyguanosine, an oxidative stress marker. In summary, welding fumes enhanced IL-24 expression in HDMEC, stimulating keratinocyte survival and migration. IL-24 expression in endothelial cells may act as an adaptive response to welding-fume exposure in the skin.

Indexed as

Cell MovementCell SurvivalInterleukinsKeratinocytesUp-RegulationWeldingAdultAir Pollutants, OccupationalCells, CulturedEndothelial CellsHumansInterleukin-24MaleMiddle AgedOccupational ExposureOxidative StressAir Pollutants, OccupationalInterleukin-24Interleukinsendothelial cellsIL-24keratinocytesoxidative stressWelding fumes

Identifiers

PMID38940434
PMCPMC11890098

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.