Evidence map›Paper›PMID 38940922›Full record

ArticleCellular and molecular life sciences : CMLS2024

Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1.

Andrea Seldeslachts, Eivind Andreas Baste Undheim, Joris Vriens, Jan Tytgat, Steve Peigneur

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Processionary Moth Exposure in Europe: Toxic-Irritant and Immunoglobulin E-Mediated Endotypes, Diagnosis and Management.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  2. Quantification of Urticating Setae of Oak Processionary Moth (International journal of environmental research and public health · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea SeldeslachtsToxicology and Pharmacology, Department Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium.
Eivind Andreas Baste UndheimCentre for Biochemistry and Molecular Biology, Department of Biosciences, The University of Oslo, Oslo, Norway.
Joris VriensLaboratory of Endometrium, Endometriosis and Reproductive Medicine, Department of Development and Regeneration, KU Leuven, Leuven, Vlaams-Brabant, Belgium.
Jan TytgatToxicology and Pharmacology, Department Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium. jan.tytgat@kuleuven.be.ORCID http://orcid.org/0000-0003-1778-6022
Steve PeigneurToxicology and Pharmacology, Department Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium. steve.peigneur@kuleuven.be.

Funding

European Cooperation in Science and Technology CA19144 EUVENFonds Wetenschappelijk Onderzoek 12W7822NFonds Wetenschappelijk Onderzoek 1S51521NFonds Wetenschappelijk Onderzoek 1S51523NFonds Wetenschappelijk Onderzoek G0E7120NFonds Wetenschappelijk Onderzoek GOA4919NFonds Wetenschappelijk Onderzoek GOC2319NH2020 European Research Council 101039862Norwegian Research Council FRIPRO-YRT Fellowship no. 287462
6 · The paper itself

Abstract

As human skin comes into contact with the tiny hairs or setae of the oak processionary caterpillar, Thaumetopoea processionea, a silent yet intense chemical confrontation occurs. The result is a mix of issues: skin rashes and an intense itching that typically lasts days and weeks after the contact. This discomfort poses a significant health threat not only to humans but also to animals. In Western Europe, the alarming increase in outbreaks extends beyond areas near infested trees due to the dispersion of the setae. Predictions indicate a sustained rise in outbreaks, fueled by global changes favoring the caterpillar's survival and distribution. Currently, the absence of an efficient treatment persists due to significant gaps in our comprehension of the pathophysiology associated with this envenomation. Here, we explored the interaction between the venom extract derived from the setae of T. processionea and voltage- and ligand-gated ion channels and receptors. By conducting electrophysiological analyses, we discovered ex vivo evidence highlighting the significant role of TPTX

Indexed as

TRPV Cation ChannelsAnimalsArthropod VenomsHumansLarvaMothsSkinArthropod VenomsTRPV1 protein, humanTRPV Cation ChannelsContact dermatitisItchSecapin-like peptide toxin and electrophysiologyThaumetopoea processioneaTRPV1

Identifiers

PMID38940922
PMCPMC11335206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.