Evidence map›Paper›PMID 38940930›Full record

ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2024

Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology.

Zsolt Pirger, Péter Urbán, Bence Gálik, Bence Kiss, Antal Tapodi, János Schmidt, Gábor K Tóth, Joris M Koene, György Kemenes, Dóra Reglődi and 2 more

Abstract read
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In one paragraph

Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zsolt PirgerEcophysiological and Environmental Toxicological Research Group, HUN-REN Balaton Limnological Research Institute, Tihany, 8237, Hungary.
Péter UrbánGenomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, Pécs, 7624, Hungary.
Bence GálikGenomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, Pécs, 7624, Hungary.
Bence KissInstitute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, 7624, Hungary.
Antal TapodiInstitute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, 7624, Hungary.
János SchmidtInstitute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, 7624, Hungary.
Gábor K TóthDepartment of Medical Chemistry, University of Szeged, Szeged, Hungary.
Joris M KoeneEcology & Evolution, Amsterdam Institute for Life and Environment, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands.
György KemenesSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK.
Dóra ReglődiDepartment of Anatomy, ELKH-PTE PACAP Research Team, Centre for Neuroscience, Medical School, University of Pécs, Pécs, 7624, Hungary.
Tibor KissEcophysiological and Environmental Toxicological Research Group, HUN-REN Balaton Limnological Research Institute, Tihany, 8237, Hungary.
István FodorEcophysiological and Environmental Toxicological Research Group, HUN-REN Balaton Limnological Research Institute, Tihany, 8237, Hungary. fodor.istvan@blki.hu.

Funding

Biotechnology and Biological Sciences Research Council BB/H009906/1Biotechnology and Biological Sciences Research Council BB/P00766X/1;
6 · The paper itself

Abstract

Evidence has been accumulating that elements of the vertebrate pituitary adenylate cyclase-activating polypeptide (PACAP) system are missing in non-chordate genomes, which is at odds with the partial sequence-, immunohistochemical-, and physiological data in the literature. Multilevel experiments were performed on the great pond snail (Lymnaea stagnalis) to explore the role of PACAP in invertebrates. Screening of neuronal transcriptome and genome data did not reveal homologs to the elements of vertebrate PACAP system. Despite this, immunohistochemical investigations with an anti-human PAC

Indexed as

Pituitary Adenylate Cyclase-Activating PolypeptideAnimalsCyclic AMPLymnaeaNeuronsReceptors, Pituitary Adenylate Cyclase-Activating PolypeptideCyclic AMPPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating PolypeptideEvolutionLymnaea stagnalisPACAPPhysiologyProtostomes

Identifiers

PMID38940930
PMCPMC11551080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.