ArticleCell reports2024
Hair follicles modulate skin barrier function.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Novel dermis niche equivalent based on a 3D-structure fabricated by 2-photon polymerization.Biomaterials and biosystems · 2026Article
- ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease.The Journal of investigative dermatology · 2026Article
- METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis.PLoS genetics · 2026Article
- Taurine-based Active Pharmaceutical Ingredient Ionic Liquids Modulate the Perifollicular Microenvironment for Androgenic Alopecia Treatment.Advanced healthcare materials · 2026Article
- Cell Death by Holocrine Secretion: The Final Step of Epithelial Differentiation in Sebaceous Glands.Cells · 2026Review
- A mouse model of meibomian gland hyperkeratinization-induced dry eye.Developmental biology · 2026Article
- Improving wound healing function and storage stability of stem cell-derived extracellular vesicles via lyophilized hyaluronic acid formulation.Journal of nanobiotechnology · 2026Article
- Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis.JCI insight · 2025Article
- Quantitative lipidomics profiling of skin surface lipids and skin barrier function evaluation in patients with acne vulgaris.Archives of dermatological research · 2025Article
- Article
- Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity.EMBO molecular medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Our skin provides a protective barrier that shields us from our environment. Barrier function is typically associated with the interfollicular epidermis; however, whether hair follicles influence this process remains unclear. Here, we utilize a potent genetic tool to probe barrier function by conditionally ablating a quintessential epidermal barrier gene, Abca12, which is mutated in the most severe skin barrier disease, harlequin ichthyosis. With this tool, we deduced 4 ways by which hair follicles modulate skin barrier function. First, the upper hair follicle (uHF) forms a functioning barrier. Second, barrier disruption in the uHF elicits non-cell-autonomous responses in the epidermis. Third, deleting Abca12 in the uHF impairs desquamation and blocks sebum release. Finally, barrier perturbation causes uHF cells to move into the epidermis. Neutralizing IL-17a, whose expression is enriched in the uHF, partially alleviated some disease phenotypes. Altogether, our findings implicate hair follicles as multi-faceted regulators of skin barrier function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.