Evidence map›Paper›PMID 38942744›Full record

ArticleNPJ genomic medicine2024

Rare variants at KCNJ2 are associated with LDL-cholesterol levels in a cross-population study.

Niccolò Rossi, Najeeb Syed, Alessia Visconti, Elbay Aliyev, Sarah Berry, Mafalda Bourbon, Tim D Spector, Pirro G Hysi, Khalid A Fakhro, Mario Falchi

Abstract read
In one paragraph

Article in NPJ genomic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niccolò RossiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Najeeb SyedDepartment of Human Genetics, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0003-0460-5237
Alessia ViscontiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4144-2019
Elbay AliyevDepartment of Human Genetics, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0002-6469-1854
Sarah BerryDepartment of Nutritional Sciences, King's College London, London, UK.
Mafalda BourbonCardiovascular Research Group, Department of Health Promotion and Prevention of non-Communicable Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal.
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Pirro G HysiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Khalid A FakhroDepartment of Human Genetics, Sidra Medical and Research Center, Doha, Qatar.ORCID http://orcid.org/0000-0002-3150-1276
Mario FalchiDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK. mario.falchi@kcl.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Leveraging whole genome sequencing data of 1751 individuals from the UK and 2587 Qatari subjects, we suggest here an association of rare variants mapping to the sour taste-associated gene KCNJ2 with reduced low-density lipoprotein cholesterol (LDL-C, P = 2.10 × 10

Identifiers

PMID38942744
PMCPMC11213907

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.