Evidence map›Paper›PMID 38943337›Full record

Observational studyEndocrinology, diabetes & metabolism2024

Comparative Determination of Mitochondrial Biomarkers and Their Relationship With Insulin Resistance in Type 2 Diabetic Patients: An Observational Cross-Sectional Study.

Emmanuel K Ofori, Wormenor Dziedzorm, Alfred Buabeng, Francis K Dogodzi, Laurinda X Adusu-Donkor, Segla K Bernard, Seth K Amponsah, Henry Asare-Anane

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In one paragraph

Observational study in Endocrinology, diabetes & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emmanuel K OforiDepartment of Chemical Pathology, UGMS, University of Ghana, Accra, Ghana.
Wormenor DziedzormParadise Diagnostic Centre, Abeka-Lapaz, Accra, Ghana.
Alfred BuabengSt. Gregory Hospital, Buduburam, Central Region, Ghana.
Francis K DogodziSchool of Veterinary Medicine, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Laurinda X Adusu-Donkor37 Military Hospital, Accra, Ghana.
Segla K BernardWest African Centre for Cell Biology of Infectious Pathogens, Accra, Ghana.
Seth K AmponsahDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
Henry Asare-AnaneDepartment of Chemical Pathology, UGMS, University of Ghana, Accra, Ghana.

Funding

BANGA-Africa Seed Grant Scheme UG-BA/SRG-001/2021
6 · The paper itself

Abstract

introductionData suggest malfunctioning mitochondria reduce oxidation and adenosine triphosphate (ATP) production, disrupting insulin signalling. Cytochrome c (CC), acylcarnitine (AC) and citrate synthase (CS) are essential components of the mitochondria machinery and can be used as reliable biomarkers of mitochondrial dysfunction. This study aimed to determine whether mitochondrial biomarkers (AC, CS and CC) are altered in individuals with type 2 diabetes mellitus (T2DM) and to examine the association between these biomarkers and insulin resistance. METHODOLOGY: A cross-sectional observational study that recruited 170 participants (88 with T2DM and 82 without DM) was conducted. Blood samples were collected from the recruits and analysed for levels of fasting glucose (FBG), AC, CS, CC, insulin, total cholesterol, triglycerides (TG), glycated haemoglobin (HbA1c) and magnesium. Blood pressure (BP) and anthropometric characteristics of participants were also taken. Appropriate formulas were used to determine %body fat, body mass index (BMI), waist-to-hip ratio (WHR), the homeostatic model assessment for insulin resistance (HOMA-IR) and insulin sensitivity (HOMA-β).

resultsPatients with T2DM had higher levels of CC, %body fat, FBG, TG, HbA1c, BMI and HOMA-IR than controls (p < 0.05, respectively). Results showed a significant relationship between circulating CC levels versus HOMA-β (r = -0.40, p = 0.001), CS (r = -0.70, p = 0.001) and AC (r = -0.72, p = 0.001) levels in patients with T2DM. The adjusted odds increased in the T2DM patients for VLDL (OR = 6.66, p = 0.002), HbA1c (OR = 6.50, p = 0.001), FPG (OR = 3.17, p = 0.001), TG (OR = 2.36, p = 0.010), being female (OR = 2.09, p = 0.020) and CC (OR = 1.14, p = 0.016).

conclusionOverall, alterations in mitochondrial biomarkers, measured by AC, CC and CS, were observed in people with T2DM and showed a direct relationship with insulin resistance. These findings are potentially significant in Africa, although additional confirmation from a larger cohort is necessary.

Indexed as

BiomarkersDiabetes Mellitus, Type 2Insulin ResistanceMitochondriaAdultAgedBlood GlucoseBody Mass IndexCarnitineCitrate (si)-SynthaseCross-Sectional StudiesCytochromes cFemaleGlycated HemoglobinHumansMaleacylcarnitineBiomarkersBlood GlucoseCarnitineCitrate (si)-SynthaseCytochromes cGlycated Hemoglobinacylcarnitinecitrate synthasecytochrome cmitochondriatype 2 diabetes

Identifiers

PMID38943337
PMCPMC11213964

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.