Evidence map›Paper›PMID 38945551›Full record

ArticleKorean journal of anesthesiology2024

Effect of lipid emulsion on vasoconstriction induced by epinephrine or norepinephrine in isolated rat aorta.

Soo Hee Lee, Kyeong-Eon Park, Kibaek Eum, Yeran Hwang, Seong-Ho Ok, Gyujin Sim, Dumidu Perera, Henri K M Ravald, Youngho Park, Susanne K Wiedmer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Soo Hee LeeDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Kyeong-Eon ParkDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.
Kibaek EumGyeongsang National University College of Medicine, Jinju, Korea.
Yeran HwangDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea.
Seong-Ho OkDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Gyujin SimInstitute of Medical Science, Gyeongsang National University, Jinju, Korea.
Dumidu PereraDepartment of Chemistry, University of Helsinki, Helsinki, Finland.
Henri K M RavaldDepartment of Chemistry, University of Helsinki, Helsinki, Finland.
Youngho ParkDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea.
Susanne K WiedmerDepartment of Chemistry, University of Helsinki, Helsinki, Finland.
Ju-Tae SohnInstitute of Medical Science, Gyeongsang National University, Jinju, Korea.

Funding

Finnish Society of Sciences and Letters 4709946Ministry of Education RS-2023-00238572National Research Foundation of Korea 2021R1F1A1062363National Research Foundation of Korea 2021R1I1A3040332Waldemar von Frenckell Foundation 4706562
6 · The paper itself

Abstract

backgroundEpinephrine (EPI) or norepinephrine (NOR) is widely used to treat cardiovascular collapse during lipid emulsion (LE) resuscitation for drug toxicity. However, the effect of LE on the vasoconstriction caused by EPI or NOR remains unknown. The purpose of this study was to examine the effect of an LE (Intralipid) on the vasoconstriction caused by EPI and NOR in isolated rat aorta.

methodsThe effect of LE on the vasoconstriction caused by EPI or NOR in isolated rat aorta was examined. Additionally, the effect of LE on the calcium increase caused by EPI or NOR was investigated. The distribution constant (KD: lipid to aqueous phase) of EPI or NOR between a LE (1%) and an aqueous phase was determined.

resultsLE (1 and 2%) did not significantly alter vasoconstriction caused by EPI or NOR in isolated endothelium-intact aorta. Moreover, the LE did not significantly alter the increased calcium level caused by EPI or NOR. The log KD of EPI in the LE (1%) was -0.71, -0.99, and -1.00 at 20, 50, and 100 mM ionic strength, respectively. The log KD of NOR in the LE (1%) was -1.22, -1.25, and -0.96 at 20, 50, and 100 mM ionic strength, respectively.

conclusionsTaken together, the Intralipid emulsion did not alter vasoconstriction induced by EPI or NOR that seems to be due to the hydrophilicity of EPI or NOR, leading to sustained hemodynamic support produced by EPI or NOR used during LE resuscitation.

Indexed as

EmulsionsEpinephrineFat Emulsions, IntravenousNorepinephrineSoybean OilVasoconstrictionVasoconstrictor AgentsAnimalsAortaCalciumIn Vitro TechniquesMalePhospholipidsRatsRats, Sprague-DawleyRats, WistarCalciumEmulsionsEpinephrineFat Emulsions, IntravenousNorepinephrinePhospholipidsSoybean Oilsoybean oil, phospholipid emulsionVasoconstrictor AgentsDistribution constantEpinephrineIntralipidIntravenous fat emulsionsLipid emulsionNorepinephrineVasoconstriction.

Identifiers

PMID38945551
PMCPMC11467498

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.