Causal relationship between type 1 diabetes mellitus and mycoses: a Mendelian randomization study.

Xiaolan Chen, Chen Chen, Mingyan Wu, Shanmei Wang, Hongbin Jiang, Zhe Li, Yuetian Yu, Bing Li

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Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Xiaolan Chen *Department of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Chen Chen *Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Mingyan WuDepartment of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Shanmei WangDepartment of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Hongbin JiangDepartment of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Zhe LiDepartment of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Yuetian YuDepartment of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Bing LiDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 1 diabetes mellitus (T1DM) is frequently associated with various infections, including mycoses; however, the direct link between T1DM and fungal infections remains under-researched. This study utilizes a Mendelian randomization (MR) approach to investigate the potential causal relationship between T1DM and mycoses. Methods: Genetic variants associated with T1DM were sourced from the European Bioinformatics Institute database, while those related to fungal infections such as candidiasis, pneumocystosis, and aspergillosis were obtained from the Finngen database, focusing on European populations. The primary analysis was conducted using the inverse variance weighted (IVW) method, with additional insight from Mendelian randomization Egger regression (MR-Egger). Extensive sensitivity analyses assessed the robustness, diversity, and potential horizontal pleiotropy of our findings. Multivariable Mendelian randomization (MVMR) was employed to adjust for confounders, using both MVMR-IVW and MVMR-Egger to evaluate heterogeneity and pleiotropy. Results: Genetically, the odds of developing candidiasis increased by 5% in individuals with T1DM, as determined by the IVW method (OR = 1.05; 95% CI 1.02-1.07, Conclusion: This MR study suggests a genetic predisposition for increased susceptibility to candidiasis in individuals with T1DM. However, no causal links were established between T1DM and other mycoses, including aspergillosis and pneumocystosis.

Indexed as

candidiasisdiabetes mellitus type 1infectionsMendelian randomization analysismycoses

Identifiers

PMID38947239

DOI10.3389/fmed.2024.1408297

PMCPMC11211379

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.