Evidence map›Paper›PMID 38947879›Full record

ArticleJournal of extracellular biology2024

P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes.

Mohammad Abdullah, Zhi Ruan, Seiko Ikezu, Tsuneya Ikezu

Erratum issuedAbstract read
In one paragraph

Article in Journal of extracellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Extracellular Vesicle-Mediated Neuron-Glia Communications in the Central Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mohammad AbdullahDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Zhi RuanDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Seiko IkezuDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Tsuneya IkezuDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.ORCID https://orcid.org/0000-0002-3979-8596

Funding

Exosome-mediated propagation of pathogenic tau proteinRF1AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2016 to 2021
$5.0M
Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1M
Molecular characterization of extracellular vesicles for the spread of misfolded tau proteinR01AG067763 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$3.1M
Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse modelR01AG072719 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$2.7M
Therapeutic evaluation of targeting Tau Tubulin kinase-1 in Alzheimer’s diseaseR01AG079859 · NIA · MAYO CLINIC JACKSONVILLE · PI Seiko Ikezu · 2023 to 2026
$2.2M
Tumor susceptibility gene 101, a new microglial therapy candidate for Alzheimer’s disease to prevent cognitive declineRF1AG082704 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, SEIKO, IKEZU, TSUNEYA · 2023 to 2023
$2.0M
Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's diseaseR01AG066429 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2020 to 2024
$2.0M
APOE and microglia-mediated progression in tau pathology in ADR01AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2024 to 2025
$1.4M
NIA NIH HHS R01 AG054199NIA NIH HHS R01 AG054672NIA NIH HHS R01 AG066429NIA NIH HHS R01 AG067763NIA NIH HHS R01 AG072719NIA NIH HHS R01 AG079859NIA NIH HHS RF1 AG054199NIA NIH HHS RF1 AG082704
6 · The paper itself

Abstract

Extracellular vesicle (EV) secretion is mediated by purinergic receptor P2X

Indexed as

astrocytesATPCD9extracellular vesicleflotillin‐1GSK1482160microgliaP2RX7Tsg101

Identifiers

PMID38947879
PMCPMC11212328

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.