Evidence map›Paper›PMID 38948727›Full record

ArticlebioRxiv : the preprint server for biology2024

Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An

Antonio J Rua, Wayne Mitchell, Steven M Claypool, Nathan N Alder, Andrei T Alexandrescu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Antonio J RuaDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0009-0001-5823-9706
Wayne MitchellDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-0871-2080
Steven M ClaypoolDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5316-1623
Nathan N AlderDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-4474-7803
Andrei T AlexandrescuDepartment of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-8425-9276

Funding

First-in-class peptide therapeutics for mitochondrial disorders: molecular mechanism of action and optimization of designR01AG065879 · NIA · UNIVERSITY OF CONNECTICUT STORRS · PI ALDER, NATHAN N · 2020 to 2024
$2.6M
NIA NIH HHS R01 AG065879
6 · The paper itself

Abstract

Mitochondria are central to cellular metabolism; hence, their dysfunction contributes to a wide array of human diseases including cancer, cardiopathy, neurodegeneration, and heritable pathologies such as Barth syndrome. Cardiolipin, the signature phospholipid of the mitochondrion promotes proper cristae morphology, bioenergetic functions, and directly affects metabolic reactions carried out in mitochondrial membranes. To match tissue-specific metabolic demands, cardiolipin typically undergoes an acyl tail remodeling process with the final step carried out by the phospholipid-lysophospholipid transacylase tafazzin. Mutations in the

Indexed as

3-methylglutaconic acid (3MGA)adenosine triphosphate (ATP)Barth syndrome (BTHS)Krebs cyclemetabolic diseasemitochondrial respirationnuclear magnetic resonance (NMR)tricarboxylic acid (TCA) cycle

Identifiers

PMID38948727
PMCPMC11212973

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.