Evidence map›Paper›PMID 38948734›Full record

ArticlebioRxiv : the preprint server for biology2024

HumanIslets: An integrated platform for human islet data access and analysis.

Jessica D Ewald, Yao Lu, Cara E Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore Dos Santos, Aliya F Spigelman, Austin Bautista and 23 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Jessica D EwaldInstitute of Parasitology, McGill University, Montreal, QC.
Yao LuInstitute of Parasitology, McGill University, Montreal, QC.
Cara E EllisAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Jessica WortonAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Jelena KolicDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC.
Shugo SasakiDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Dahai ZhangDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Theodore Dos SantosAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Aliya F SpigelmanAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Austin BautistaAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Xiao-Qing DaiAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
James G LyonAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Nancy P SmithAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Jordan M WongAlberta Diabetes Institute, University of Alberta, Edmonton, AB.
Varsha RajeshDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA.
Han SunDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA.
Seth A SharpDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA.
Jason C RogalskiDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC.
Renata MoravcovaDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC.
Haoning H CenDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC.ORCID 0000-0001-8045-1335
Jocelyn E Manning FoxAlberta Diabetes Institute, University of Alberta, Edmonton, AB.ORCID 0000-0002-4157-2094
HI-DAS Consortium
Ella AtlasEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON.ORCID 0000-0003-4410-4402
Jennifer E BruinDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, ON.ORCID 0000-0003-2326-7819
Erin E MulvihillDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, ON.
C Bruce VerchereDepartment of Surgery, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC.ORCID 0000-0002-9262-0586
Leonard J FosterDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC.ORCID 0000-0001-8551-4817
Anna L GloynDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA.ORCID 0000-0003-1205-1844
James D JohnsonDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC.ORCID 0000-0002-7523-9433
Andrew R PepperAlberta Diabetes Institute, University of Alberta, Edmonton, AB.ORCID 0000-0002-2227-4446
Francis C LynnDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-9318-1063
Jianguo XiaInstitute of Parasitology, McGill University, Montreal, QC.ORCID 0000-0003-2040-2624
Patrick E MacDonaldAlberta Diabetes Institute, University of Alberta, Edmonton, AB.ORCID 0000-0002-5439-6288

Funding

The Human Pancreas Analysis Program for Type 2 DiabetesU01DK123594 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi, KLAUS H KAESTNER · 2019 to 2026
$25.0M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
Supplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4M
Human Pancreas Analysis Program-T2DU01DK123716 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., BOTTINO, RITA · 2019 to 2024
$6.6M
Linking islet cell function and identity from in vitro to in situU01DK120447 · NIDDK · UNIVERSITY OF ALBERTA · PI ARROJO E DRIGO, RAFAEL, LUNDBERG, EMMA · 2018 to 2021
$3.0M
Identifying variants causal for Type 2 Diabetes in Major human populationsU01DK085545 · NIDDK · UNIVERSITY OF OXFORD · PI CHAN, JULIANA CN, EBRAHIM, SHAH BRIAN · 2009 to 2013
$2.8M
Integrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7M
NIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK105535NIDDK NIH HHS U01 DK120447NIDDK NIH HHS U01 DK123594NIDDK NIH HHS U01 DK123716NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UC4 DK112232NIDDK NIH HHS UM1 DK126185Wellcome Trust
6 · The paper itself

Abstract

Comprehensive molecular and cellular phenotyping of human islets can enable deep mechanistic insights for diabetes research. We established the Human Islet Data Analysis and Sharing (HI-DAS) consortium to advance goals in accessibility, usability, and integration of data from human islets isolated from donors with and without diabetes at the Alberta Diabetes Institute (ADI) IsletCore. Here we introduce HumanIslets.com, an open resource for the research community. This platform, which presently includes data on 547 human islet donors, allows users to access linked datasets describing molecular profiles, islet function and donor phenotypes, and to perform various statistical and functional analyses at the donor, islet and single-cell levels. As an example of the analytic capacity of this resource we show a dissociation between cell culture effects on transcript and protein expression, and an approach to correct for exocrine contamination found in hand-picked islets. Finally, we provide an example workflow and visualization that highlights links between type 2 diabetes status, SERCA3b Ca

Identifiers

PMID38948734
PMCPMC11212983

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.