Evidence map›Paper›PMID 38952156›Full record

SynthesisCurrent topics in medicinal chemistry2024

The Search for Drugs Derived from Natural Products for

Fabielle Marques-Santos, Robson Xavier Faria, Maria Regina Reis Amendoeira

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current topics in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Quercetin ReducesInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fabielle Marques-SantosFundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil.
Robson Xavier FariaFundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Avaliação e Promoção da Saúde Ambiental, Rio de Janeiro, RJ, Brasil.
Maria Regina Reis AmendoeiraFundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionToxoplasmosis is a worldwide distributed zoonosis caused by

methodSulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological toxicity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone marrow suppression.

resultsThe limited effect, significant toxicity, and emerging resistance to current drugs available to treat

Indexed as

Biological ProductsToxoplasmaToxoplasmosisAnimalsAntiprotozoal AgentsHumansAntiprotozoal AgentsBiological ProductsImmunocompetent.PhytotherapyPlant extractToxicityToxoplasma gondiiToxoplasmosis

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.