Evidence map›Paper›PMID 38952983›Full record

ArticlePeerJ2024

ULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3.

Xiaoxi Chen, Changxiang Shao, Jing Liu, Huizhen Sun, Bingyi Yao, Chengbin Ma, Han Xu, Weipei Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoxi Chen *Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Changxiang Shao *Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Jing LiuChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Huizhen SunDepartment of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Bingyi YaoChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Chengbin MaChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Han XuDepartment of General Surgery, Jing'an District Center Hospital of Shanghai, Shanghai, China.
Weipei ZhuThe Second Affiliated Hospital of Soochow University, Soochow University, Soochow, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in the progression of ovarian cancer. Methods: ULK2 expression patterns in ovarian cancer tissues as well as benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 and Transwell assays were applied to assess the effects of ULK2 overexpression on cell proliferation, migration and invasion, respectively. RNA sequencing was performed to explore potential mechanisms of action of ULK2 beyond its classical autophagy modulation. Results: Our experiments showed significant downregulation of ULK2 in ovarian cancer tissues. Importantly, low expression of ULK2 was markedly correlated with decreased overall survival. Conclusions: In summary, the collective data indicated that ULK2 acted as a tumor suppressor in ovarian cancer by upregulating the expression of IGFBP3. Our study underscores the potential utility of ULK2 as a valuable prognostic marker for ovarian cancer.

Indexed as

Cell MovementCell ProliferationInsulin-Like Growth Factor Binding Protein 3Neoplasm InvasivenessOvarian NeoplasmsAutophagy-Related Protein-1 HomologCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansProtein Serine-Threonine KinasesSignal TransductionUp-RegulationAutophagy-Related Protein-1 HomologIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Protein Serine-Threonine KinasesUlk2 protein, humanIGFBP3Insulin signaling pathwayInvasionMigrationOvarian cancerULK2

Identifiers

PMID38952983
PMCPMC11216209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.