Evidence map›Paper›PMID 38954474›Full record

ArticleJCI insight2024

Iron capture through CD71 drives perinatal and tumor-associated Treg expansion.

Ilenia Pacella, Alessandra Pinzon Grimaldos, Alessandra Rossi, Gloria Tucci, Marta Zagaglioni, Elena Potenza, Valeria Pinna, Ivano Rotella, Ilenia Cammarata, Valeria Cancila and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Iron and the immune system.Nature reviews. Immunology · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Enhanced CRC Growth in Iron-Rich Environment, Facts and Speculations.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Ilenia PacellaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra Pinzon GrimaldosDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra RossiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Gloria TucciDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Marta ZagaglioniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Elena PotenzaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Valeria PinnaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Ivano RotellaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Ilenia CammarataDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Valeria CancilaTumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy.
Beatrice BelmonteTumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy.
Claudio TripodoTumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy.
Giuseppe PietropaoloDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Chiara Di CensoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giuseppe SciumèDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Valerio LicursiInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy, Sapienza University of Rome, Rome, Italy.
Giovanna PeruzziCentre for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.
Ylenia AntonucciDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Silvia CampelloDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Francesca GuerrieriCancer Research Centre of Lyon (CRCL), UMR Inserm U1052/CNRS 5286, Lyon, France.
Valerio IebbaDepartment of Medical, Surgical, and Health Sciences, University of Trieste, Trieste, Italy.
Rita ProtaDepartment of Maternal and Child Health, Sapienza University of Rome, Rome, Italy.
Maria Di ChiaraDepartment of Maternal and Child Health, Sapienza University of Rome, Rome, Italy.
Gianluca TerrinDepartment of Maternal and Child Health, Sapienza University of Rome, Rome, Italy.
Valerio De PeppoHepatobiliary and Pancreatic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Gian Luca GraziHepatobiliary and Pancreatic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Vincenzo BarnabaLaboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Silvia PiconeseDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides suppressing immune responses, regulatory T cells (Tregs) maintain tissue homeostasis and control systemic metabolism. Whether iron is involved in Treg-mediated tolerance is completely unknown. Here, we showed that the transferrin receptor CD71 was upregulated on activated Tregs infiltrating human liver cancer. Mice with a Treg-restricted CD71 deficiency spontaneously developed a scurfy-like disease, caused by impaired perinatal Treg expansion. CD71-null Tregs displayed decreased proliferation and tissue-Treg signature loss. In perinatal life, CD71 deficiency in Tregs triggered hepatic iron overload response, characterized by increased hepcidin transcription and iron accumulation in macrophages. Lower bacterial diversity, and reduction of beneficial species, were detected in the fecal microbiota of CD71 conditional knockout neonates. Our findings indicate that CD71-mediated iron absorption is required for Treg perinatal expansion and is related to systemic iron homeostasis and bacterial gut colonization. Therefore, we hypothesize that Tregs establish nutritional tolerance through competition for iron during bacterial colonization after birth.

Indexed as

Antigens, CDIronReceptors, TransferrinT-Lymphocytes, RegulatoryAnimalsFemaleGastrointestinal MicrobiomeHomeostasisHumansLiverLiver NeoplasmsMaleMiceMice, KnockoutAntigens, CDCD71 antigenIronReceptors, TransferrinImmunologyMetabolismT cellsTolerance

Identifiers

PMID38954474
PMCPMC11383606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.