ArticleThe Journal of clinical endocrinology and metabolism2025
Association of Physical Activity Patterns With Nocturnal Hypoglycemia Events in Youth With Type 1 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in glycemic outcomes: a systematic review and meta-analysis of diabetes treatments.BMJ open diabetes research & care · 2026Pooled it
- Prediction of Nocturnal Hypoglycemia Following Exercise in Type 1 Diabetes Using Temporally Structured CGM-Derived Digital Biomarkers.Sensors (Basel, Switzerland) · 2026Article
- Multimodal Physiological Monitoring Using Novel Wearable Sensors: A Pilot Study on Nocturnal Glucose Dynamics and Meal-Related Cardiovascular Responses.Bioengineering (Basel, Switzerland) · 2026Article
- Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework.Frontiers in public health · 2026Review
- Scale-up of the Diactive-1 mHealth program integrating tailored resistance training as an educational strategy for self-management in children and adolescents with type 1 diabetes: protocol for an 11-hospital multicenter randomized controlled trial.Frontiers in endocrinology · 2026Article
- Unmet needs in the treatment of type 1 diabetes: why is it so difficult to achieve an improvement in metabolic control?Nutrition & diabetes · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsThis study sought to elucidate the interactions among physical activity (PA) patterns, mean glucose concentrations, and the incidence of nocturnal hypoglycemia events in children and adolescents with type 1 diabetes, examining the moderating influence of daily dosage on these associations.
methodsEighty-two participants aged 6 to 18 years (43.9% girls) from the Diactive-1 Cohort Study, diagnosed with type 1 diabetes, were included. Data collection involved continuous glucose monitoring, accelerometry to assess real-world PA, as well as documentation of daily insulin doses and carbohydrate counting over the same 7 days.
resultsA total of 19 participants experienced at least 1 nocturnal hypoglycemia event over a span of 574 measurement days (106 days with and 451 days without nocturnal hypoglycemia). Higher levels of vigorous PA (VPA) were associated with lower same-day mean glucose levels (P = .014). Additionally, higher levels of moderate PA (P = .023), VPA (P = .011), and moderate-to-vigorous PA (P = .010) were associated with a greater number of nocturnal hypoglycemia events. Specifically, a significant association was identified between VPA and nocturnal hypoglycemia events when the daily insulin dose was at or above 1.04 units per kilogram of body weight per day (P = .016).
conclusionDaily VPA is associated with glucose reductions, potentially leading to more hypoglycemic episodes, particularly when there is an excess of daily insulin. This highlights the need for careful insulin management in children and adolescents with type 1 diabetes engaging in VPA.
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