Evidence map›Paper›PMID 38955655›Full record

ArticleTrends in parasitology2024

Weep and sweep and the broom: tuft cell acetylcholine limits the worm.

Alexander Perniss, Lora G Bankova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in parasitology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander PernissDivision of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.
Lora G BankovaDivision of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: lbankova@bwh.harvard.edu.

Funding

Immune dysregulation mechanisms of persistent post-COVID19 olfactory dysfunctionR01DC021425 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI Lora Bankova · 2024 to 2026
$1.9M
Allergen-elicited signaling cascades in olfactory microvillous tuft cellsR21AI185057 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BANKOVA, LORA · 2024 to 2025
$476k
NIAID NIH HHS R21 AI185057NIDCD NIH HHS R01 DC021425
6 · The paper itself

Abstract

Two studies defined how tuft cell acetylcholine promotes parasite expulsion. Billip et al. demonstrated that acetylcholine increases water secretion, to promote the 'weep' response. Ndjim et al. found that tuft cell acetylcholine has a direct effect on worm fecundity. Both processes are only effective in the remodeled epithelium when the rare tuft cells have become abundant.

Indexed as

AcetylcholineAnimalsCaenorhabditis elegansFertilityHost-Parasite InteractionsTuft CellsAcetylcholineacetylcholinehelminth infectioninnate immunitymucosal immunitytuft cellstype 2 immunity

Identifiers

PMID38955655
PMCPMC11309886

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.