Evidence map›Paper›PMID 38957150›Full record

ReviewLab on a chip2024

Modelling the innate immune system in microphysiological systems.

Michael J Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J Hickman

Abstract readReview
In one paragraph

Review in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael J RuparHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.
Hannah HansonHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.
Stephanie RogersHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.
Brianna BotlickHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.
Steven TrimmerHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.
James J HickmanHesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA. jhickman@hesperosinc.com.ORCID 0000-0002-1621-3006

Funding

Human on a chip systems to investigate disease comorbidities common in the aged populationR44AG059511 · NIA · HESPEROS, LLC · PI HICKMAN, JAMES J, SHULER, MICHAEL L · 2018 to 2022
$4.9M
Multi-organ human-on-a-chip system to address overdose and acute and chronic efficacy and off-target toxicityUH3TR003081 · NCATS · UNIVERSITY OF CENTRAL FLORIDA · PI HICKMAN, JAMES J, SHULER, MICHAEL L · 2021 to 2021
$2.4M
NCATS NIH HHS UH3 TR003081NIA NIH HHS R44 AG059511
6 · The paper itself

Abstract

This critical review aims to highlight how modeling of the immune response has adapted over time to utilize microphysiological systems. Topics covered here will discuss the integral components of the immune system in various human body systems, and how these interactions are modeled using these systems. Through the use of microphysiological systems, we have not only expanded on foundations of basic immune cell information, but have also gleaned insight on how immune cells work both independently and collaboratively within an entire human body system.

Indexed as

Immunity, InnateAnimalsHumansLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesMicrophysiological SystemsModels, Immunological

Identifiers

PMID38957150
PMCPMC11264333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.