Evidence map›Paper›PMID 38957656›Full record

ArticleJournal of the Endocrine Society2024

Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With

Maria I Stamou, Crystal J Chiu, Shreya V Jadhav, Vanessa Ferreira Lopes, Kathryn B Salnikov, Lacey Plummer, Margaret F Lippincott, Hang Lee, Stephanie B Seminara, Ravikumar Balasubramanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Pharmacological and Biological Targeting of FGFR1 in Cancer.Current issues in molecular biology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria I StamouReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-5992-2120
Crystal J ChiuReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Shreya V JadhavReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Vanessa Ferreira LopesReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Kathryn B SalnikovReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Lacey PlummerReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Margaret F LippincottReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-3533-1999
Hang LeeMGH Biostatistics Center and MGH Division of Clinical Research (DCR) Biostatistics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Stephanie B SeminaraReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ravikumar BalasubramanianReproductive Endocrine Unit and Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-6008-5585

Funding

The Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI NEALE, BENJAMIN MICHAEL · 2014 to 2020
$12.9M
The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2021 to 2025
$7.8M
Towards Curative Therapies for Hypogonadotropic DiseasesR37HD043341 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Stephanie Beth Seminara · 2020 to 2026
$5.8M
Dissection of the Molecular Basis of Pleiotropy Between GnRH Neuronal Development and Cranial Suture FusionR01DE031452 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI Erica Ellen Davis, Stephanie Beth Seminara · 2022 to 2026
$3.9M
Integrative Approaches to Decipher Genetic Determinants of Disease Penetrance in Prokineticin 2 Pathway Related Human Reproductive DisordersR01HD096324 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BALASUBRAMANIAN, RAVIKUMAR · 2018 to 2022
$1.7M
Kisspeptin: A Novel Regulator of Insulin in PregnancyK23HD097296 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LIPPINCOTT, MARGARET FLYNN · 2019 to 2023
$864k
Deciphering the Role of Copy Number Variants in Neuroendocrine Disorders of InfertilityF32HD108873 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI STAMOU, MARIA · 2022 to 2024
$233k
FDA HHS R01 FD007843NICHD NIH HHS F32 HD108873NICHD NIH HHS K23 HD097296NICHD NIH HHS P50 HD028138NICHD NIH HHS P50 HD104224NICHD NIH HHS R01 HD096324NICHD NIH HHS R37 HD043341NIDCR NIH HHS R01 DE031452
6 · The paper itself

Abstract

Context: Activation of fibroblast growth factor receptor 1 (FGFR1) signaling improves the metabolic health of animals and humans, while inactivation leads to diabetes in mice. Direct human genetic evidence for the role of FGFR1 signaling in human metabolic health has not been fully established. Objective: We hypothesized that individuals with naturally occurring Methods: Participants with rare Conclusion: These findings suggest that impaired FGFR1 signaling may contribute to an early insulin resistance phase of diabetes pathogenesis and support the candidacy of the FGFR1 signaling pathway as a therapeutic target for improving the human metabolic health.

Indexed as

diabetesFGFR1geneticshuman mutationsinsulin resistance

Identifiers

PMID38957656
PMCPMC11216325

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.