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ArticleIndian journal of pediatrics2025

Enteroviruses Associated with Hand Foot and Mouth Disease in Navi Mumbai, Maharashtra, India in 2022.

Madhu Chhanda Mohanty, Dhanya Dharmapalan, Pooja Vengurlekar, Swapnil Varose, Anita Shete, Yash Joshi, Savita Yadav, Pragya Yadav, Ketki Jawade, Manogat Tatkare and 9 more

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Article in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Madhu Chhanda MohantyICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India. madhuerc@gmail.com.ORCID 0000-0001-6942-2875
Dhanya DharmapalanDepartment of Pediatrics, Apollo Hospitals, Navi Mumbai, Maharashtra, India.
Pooja VengurlekarICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.
Swapnil VaroseICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.
Anita SheteMaximum Containment Lab, ICMR-National Institute of Virology, MCC, Pashan, Maharashtra, India.
Yash JoshiMaximum Containment Lab, ICMR-National Institute of Virology, MCC, Pashan, Maharashtra, India.
Savita YadavMaximum Containment Lab, ICMR-National Institute of Virology, MCC, Pashan, Maharashtra, India.
Pragya YadavMaximum Containment Lab, ICMR-National Institute of Virology, MCC, Pashan, Maharashtra, India.
Ketki JawadeICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.
Manogat TatkareICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.
Jeetendra GavhaneDepartment of Pediatrics, MGM Institute of Health Sciences, Navi Mumbai, Maharashtra, India.
Asmita PatilDepartment of Pediatrics, Dr. Yewale's Multispeciality Hospital for Children, Vashi, Navi Mumbai, Maharashtra, India.
Satish ShahaneDepartment of Pediatrics, Saanvi Children Hospital, Kharghar, Navi Mumbai, India.
Suhas WaradDepartment of Pediatrics, Jack n Jill Children's Clinic, Nerul, Navi Mumbai, India.
Yashank YewaleDepartment of Pediatrics, Dr. Yewale's Multispeciality Hospital for Children, Ghansoli, Navi Mumbai, India.
Praveen ModyDepartment of Pediatrics, RJH Municipal Hospital, Airoli, Navi Mumbai, India.
Shrikrishna JoshiDepartment of Microbiology, Dr. Joshi Microbiology Lab Pvt Ltd, Vashi, Navi Mumbai, India.
Vijay YewaleDepartment of Pediatrics, Dr. Yewale's Multispeciality Hospital for Children, Vashi, Navi Mumbai, Maharashtra, India.
Vinay Kumar SaxenaICMR-National Institute of Virology, Mumbai Unit, Mumbai, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An outbreak of Hand Foot and Mouth Disease (HFMD) which occurred in August-September, 2022 in Navi Mumbai, India was prospectively investigated, to delineate the clinical manifestations and identify the etiological agent. Molecular characterization at ICMR-National Institute of Virology (NIV), Mumbai unit reported 69 (88.5%) cases out of 78 clinically diagnosed HFMD cases positive for enteroviruses. Thirty-nine (56.5%) children were positive for CVA6, 11 (15.9%) for CVA16, and one for CVA4 (1.4%). One case of co-infection (CVA16, CVA6) was reported. Fourteen (17.9%) cases had recurrent disease in the same season. CVA6 was associated with unusual extension of the rash beyond the conventional areas of hands, feet, and mouth, with involvement of body areas including face, axillae and trunk. Whole genome sequencing classified CVA6 as group D3 and CVA16 isolates as group B1c. Co-infection and recurrence of disease with atypical symptoms observed in this study highlight the need for continued vigilance of the evolutionary clinical characteristics of the enteroviruses causing HFMD.

Indexed as

Disease OutbreaksEnterovirusEnterovirus InfectionsHand, Foot and Mouth DiseaseChildChild, PreschoolCoinfectionFemaleHumansIndiaInfantMaleProspective StudiesAtypical SymptomCoxackie Virus A16Coxackie Virus A6NGSRecurrence DiseaseVesicular Rash

Identifiers

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Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.