Evidence map›Paper›PMID 38959062›Full record

ArticleeLife2024

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA.

Hao Wang, Chen Ye, Qi Lu, Zhijie Jiang, Chao Jiang, Chun Zhou, Na Li, Caiqiao Zhang, Guoping Zhao, Min Yue and 1 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao WangDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.
Chen YeDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.
Qi LuHainan Institute of Zhejiang University, Sanya, China.
Zhijie JiangDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.
Chao JiangLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.
Chun ZhouSchool of Public Health, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0002-9257-468X
Na LiDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.
Caiqiao ZhangDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-3519-9457
Guoping ZhaoKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
Min YueDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-6787-0794
Yan LiDepartment of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China.

Funding

Horizon 2020 - Research and Innovation Framework Programme 861917-SAFFIKey research and Development Program of Hangzhou 202203A08National Program on Key Research Project of China 2019YFE0103900National Program on Key Research Project of China 2022YFC2604201Scientific Research Fund of Zhejiang Provincial Education Department Y202250872Zhejiang Provincial Key R&D Program 2021C02008Zhejiang Provincial Key R&D Program 2023C03045Zhejiang Provincial Natural Science Foundation of China LZ24C180002
6 · The paper itself

Abstract

Bacterial exonuclease III (ExoIII), widely acknowledged for specifically targeting double-stranded DNA (dsDNA), has been documented as a DNA repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3'→5' exonuclease activities. Due to these enzymatic properties, ExoIII has been broadly applied in molecular biosensors. Here, we demonstrate that ExoIII (

Indexed as

DNA, Single-StrandedEscherichia coliExodeoxyribonucleasesEscherichia coli ProteinsDNA, Single-StrandedEscherichia coli Proteinsexodeoxyribonuclease IIIExodeoxyribonucleasesbiochemistrychemical biologyE. coliendonuclease activityExoⅢ-based diagnosticsexonucleaseexonuclease Ⅲfluorescence-quenching reporter

Identifiers

PMID38959062
PMCPMC11221836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.