ReviewFrontiers in medicine2024
Myocardial protection in cardiac surgery: a comprehensive review of current therapies and future cardioprotective strategies.
Review in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perioperative hyperoxia versus normoxia during cardiopulmonary bypass in adult cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2026Pooled it
- Effects of mannitol on cardiac function and postoperative arrhythmias after coronary artery bypass grafting: a randomized controlled trial.Journal of cardiothoracic surgery · 2025Trial
- Comparison of intermittent antegrade cardioplegia and antegrade/retrograde cardioplegia in cardiac surgery: A propensity-matched analysis.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- GLP-1 Receptor Agonists in Cardiac Surgery: From Metabolic Drug to Potential Perioperative Cardioprotective Agent.Journal of cardiovascular development and disease · 2026Review
- Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets.Anaesthesia · 2026Article
- Mitral valve surgery combined with on-pump coronary artery bypass grafting (CABG) versus off-pump or on-pump beating heart CABG: a retrospective cohort study.Journal of thoracic disease · 2026Article
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- A case report of right coronary artery ligation in the treatment of adult - type anomalous origin of the right coronary artery from the pulmonary artery complicated with coronary heart disease.Frontiers in cardiovascular medicine · 2026Article
- Cardioprotective Signaling: Outline and Future Directions.Biomedicines · 2025Review
- From Pandemic to Practice: How COVID-19 Has Reshaped Haemostasis in Cardiac Surgery: A Narrative Review.Journal of clinical medicine · 2025Review
- Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design.Scientific reports · 2025Article
- Protein Kinase C-β Inhibition and Survival Signaling after Simulated Cardioplegic-Ischemia/Reperfusion in Nondiabetic and Diabetic Human Coronary Arterial Endothelial Cells.Journal of the American College of Surgeons · 2025Article
- Hydrogels in Cardiac Surgery: Versatile Platforms for Tissue Repair, Adhesion Prevention, and Localized Therapeutics.Gels (Basel, Switzerland) · 2025Review
- Blood cardioplegia or custodiol for myocardial protection during valvular or aortic surgery: a propensity score adjusted comparison.Journal of cardiothoracic surgery · 2025Article
- Cancer Is a Major Determinant of Postoperative Atrial Fibrillation After Cardiac Surgery.Journal of clinical medicine · 2025Article
- Comparative Effects of HTK and St. Thomas Cardioplegia on Myocardial Outcomes and Sodium Balance in Pediatric Tetralogy of Fallot Surgery.Journal of multidisciplinary healthcare · 2025Article
- Anesthetic-mediated cardioprotection: from molecular mechanisms to clinical translation challenges.Frontiers in physiology · 2025Review
- Nicotinamide Riboside-Driven Modulation of SIRT3/mtROS/JNK Signaling Pathways Alleviates Myocardial Ischemia-Reperfusion Injury.International journal of medical sciences · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac surgery with cardiopulmonary bypass results in global myocardial ischemia-reperfusion injury, leading to significant postoperative morbidity and mortality. Although cardioplegia is the cornerstone of intraoperative cardioprotection, a number of additional strategies have been identified. The concept of preconditioning and postconditioning, despite its limited direct clinical application, provided an essential contribution to the understanding of myocardial injury and organ protection. Therefore, physicians can use different tools to limit perioperative myocardial injury. These include the choice of anesthetic agents, remote ischemic preconditioning, tight glycemic control, optimization of respiratory parameters during the aortic unclamping phase to limit reperfusion injury, appropriate choice of monitoring to optimize hemodynamic parameters and limit perioperative use of catecholamines, and early reintroduction of cardioprotective agents in the postoperative period. Appropriate management before, during, and after cardiopulmonary bypass will help to decrease myocardial damage. This review aimed to highlight the current advancements in cardioprotection and their potential applications during cardiac surgery.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.