Evidence map›Paper›PMID 38963323›Full record

ArticleeLife2024

Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum.

Ya-Juan Wang, Xiao-Jing Di, Pei-Pei Zhang, Xi Chen, Marnie P Williams, Dong-Yun Han, Raad Nashmi, Brandon J Henderson, Fraser J Moss, Ting-Wei Mu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ya-Juan Wang *Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Xiao-Jing Di *Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Pei-Pei ZhangDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Xi ChenDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Marnie P WilliamsDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Dong-Yun HanDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Raad NashmiDepartment of Biology, University of Victoria, Victoria, Canada.
Brandon J HendersonDepartment of Biomedical Sciences, Marshall University, Huntington, United States.
Fraser J MossDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0000-0002-8519-6991
Ting-Wei MuDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0000-0002-6419-9296

Funding

Understanding GABAA receptor protein folding and misfoldingR01NS105789 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Tingwei Mu · 2018 to 2026
$3.9M
Assembly Chaperone Complex for Membrane Proteins in the Endoplasmic ReticulumR01NS117176 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MU, TINGWEI · 2020 to 2023
$1.6M
NINDS NIH HHS R01 NS105789NINDS NIH HHS R01NS105789NINDS NIH HHS R01 NS117176NINDS NIH HHS R01NS117176
6 · The paper itself

Abstract

Protein homeostasis (proteostasis) deficiency is an important contributing factor to neurological and metabolic diseases. However, how the proteostasis network orchestrates the folding and assembly of multi-subunit membrane proteins is poorly understood. Previous proteomics studies identified Hsp47 (Gene:

Indexed as

Endoplasmic ReticulumReceptors, GABA-AAnimalsEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHEK293 CellsHSP47 Heat-Shock ProteinsHumansNeuronsRatsEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSP47 Heat-Shock ProteinsHSPA5 protein, humanReceptors, GABA-ASERPINH1 protein, humanSerpinh1 protein, ratassemblybiochemistrycell biologychemical biologyepilepsyfoldingGABAA receptorsHsp47humanmouseproteostasis

Identifiers

PMID38963323
PMCPMC11257679

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.