Evidence map›Paper›PMID 38966801›Full record

ArticleFrontiers in aging neuroscience2024

In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer's disease.

Lazaro M Sanchez-Rodriguez, Ahmed F Khan, Quadri Adewale, Gleb Bezgin, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Morphometric Similarity Patterning of Amyloid-International journal of molecular sciences · 2024
    Article
  9. Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lazaro M Sanchez-RodriguezDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Ahmed F KhanDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Quadri AdewaleDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Gleb BezginDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Joseph TherriaultDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Jaime Fernandez-AriasDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Stijn ServaesDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Nesrine RahmouniDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Cécile TissotDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Jenna StevensonDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Hongxiu JiangDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Xiaoqian ChaiDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Felix CarbonellBiospective Inc., Montreal, QC, Canada.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Yasser Iturria-MedinaDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms underlying neuronal dysfunction in Alzheimer's disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ) and tau deposits in the living human brain. We obtained

Indexed as

Alzheimer’s diseaseamyloid – betacomputational drug repurposinginflammationneuronal dysfunctions and alterationstau and phospho-tau proteintranscriptomicswhole-brain modeling

Identifiers

PMID38966801
PMCPMC11223503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.