Evidence map›Paper›PMID 38968807›Full record

Trial reportSchizophrenia research2024

Targeting the superior temporal gyrus with real-time fMRI neurofeedback: A pilot study of the indirect effects on self-referential processes in schizophrenia.

Francesca Morfini, Clemens C C Bauer, Jiahe Zhang, Susan Whitfield-Gabrieli, Ann K Shinn, Margaret A Niznikiewicz

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03504579 (Real-time fMRI Feedback as a Tool to Mitigate Auditory Hallucinations in Schizophrenia), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03504579 nacompletednot on this map

Real-time fMRI Feedback as a Tool to Mitigate Auditory Hallucinations in Schizophrenia

TypeinterventionalSponsorHarvard Medical School (HMS and HSDM)Ran2018 to 2022Enrolled25ConditionsAudio Visual Hallucinations, Neurofeedback, Schizophrenia, Superior Temporal GyrusArmsrt-fMRI neurofeedback
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca MorfiniNortheastern University, Department of Psychology, Boston, MA 02115, USA. Electronic address: morfini.f@northeastern.edu.
Clemens C C BauerNortheastern University, Department of Psychology, Boston, MA 02115, USA; Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge, MA 02139, USA.
Jiahe ZhangNortheastern University, Department of Psychology, Boston, MA 02115, USA.
Susan Whitfield-GabrieliNortheastern University, Department of Psychology, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, Boston, MA 02115, USA; Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA; Massachusetts Institute of Technology, McGovern Institute for Brain Research, Cambridge, MA 02139, USA.
Ann K ShinnHarvard Medical School, Department of Psychiatry, Boston, MA 02115, USA; McLean Hospital, Psychotic Disorders Division, Belmont, MA 02478, USA.
Margaret A NiznikiewiczHarvard Medical School, Department of Psychiatry, Boston, MA 02115, USA; Veterans Affairs Boston Healthcare System, Department of Psychiatry, Brockton, MA 02301, USA; Boston VA Research Institute, Boston, MA 02130, USA.

Funding

Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients with SchizophreniaR61MH113751 · NIMH · HARVARD MEDICAL SCHOOL · PI NIZNIKIEWICZ, MARGARET A, WHITFIELD-GABRIELI, SUSAN · 2018 to 2019
$1.4M
NIMH NIH HHS R61 MH113751
6 · The paper itself

Abstract

backgroundIndividuals with schizophrenia (SZ) and auditory hallucinations (AHs) display a distorted sense of self and self-other boundaries. Alterations of activity in midline cortical structures such as the prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) during self-reference as well as in the superior temporal gyrus (STG) have been proposed as neuromarkers of SZ and AHs.

methodsIn this randomized, participant-blinded, sham-controlled trial, 22 adults (18 males) with SZ spectrum disorders (SZ or schizoaffective disorder) and frequent medication-resistant AHs received one session of real-time fMRI neurofeedback (NFB) either from the STG (n = 11; experimental group) or motor cortex (n = 11; control group). During NFB, participants were instructed to upregulate their STG activity by attending to pre-recorded sentences spoken in their own voice and downregulate it by ignoring unfamiliar voices. Before and after NFB, participants completed a self-reference task where they evaluated if trait adjectives referred to themselves (self condition), Abraham Lincoln (other condition), or whether adjectives had a positive valence (semantic condition). FMRI activation analyses of self-reference task data tested between-group changes after NFB (self>semantic, post>pre-NFB, experimental>control). Analyses were pre-masked within a self-reference network.

resultsActivation analyses revealed significantly (p < 0.001) greater activation increase in the experimental, compared to the control group, after NFB within anterior regions of the self-reference network (mPFC, ACC, superior frontal cortex).

conclusionsSTG-NFB was associated with activity increase in the mPFC, ACC, and superior frontal cortex during self-reference. Modulating the STG is associated with activation changes in other, not-directly targeted, regions subserving higher-level cognitive processes associated with self-referential processes and AHs psychopathology in SZ. CLINICALTRIALS: GOV: Rt-fMRI Neurofeedback and AH in Schizophrenia; https://clinicaltrials.gov/study/NCT03504579.

Indexed as

HallucinationsMagnetic Resonance ImagingNeurofeedbackSchizophreniaTemporal LobeAdultFemaleHumansMaleMiddle AgedPilot ProjectsPsychotic DisordersSelf ConceptSingle-Blind MethodYoung AdultAuditory verbal hallucinationsfMRI task activationReal-time fMRI neurofeedbackSchizophreniaSelf-otherSelf-reference

Identifiers

PMID38968807
PMCPMC11531859

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.