SynthesisClinics (Sao Paulo, Brazil)2024
Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.
Synthesis in Clinics (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Yolk metabolomics reveals candidate compounds associated with egg specific density and hatchability in white layer breeder hens.Poultry science · 2026Article
- Review
- Investigating the effects of melatonin on structural and vascular changes in an experimentally induced ovarian hyperstimulation syndrome model : Effects of melatonin on experimentally induced ovarian hyperstimulation syndrome.Histochemistry and cell biology · 2025Article
- Melatonin in the Treatment of Female Infertility: Update on Biological and Clinical Findings.Biomedicines · 2025Article
- The Impact of Melatonin Supplementation on Various Aspects of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Health science reports · 2025Review
- Melatonin biosynthesis and regulation in reproduction.Frontiers in endocrinology · 2025Review
- Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.Reproductive biology and endocrinology : RB&E · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelatonin is a hormone produced by the pineal gland and it has antioxidant properties.
aimThis study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis. MATERIALS AND
methodsSearch strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
resultsThe main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
conclusionsMelatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.