ArticleScientific reports2024
Exploring the impacts of risk factors on mortality patterns of global Alzheimer's disease and related dementias from 1990 to 2021.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Uncovering Necroptosis in Alzheimer's Disease: A Systematic Review of Evidence Across Experimental Models.Cellular and molecular neurobiology · 2025Pooled it
- FDA Approval of Donanemab-azbt: A New Dawn in Alzheimer's Disease Treatment.Health science reports · 2026Article
- Dementia and all-cause mortality in older adults: Findings from the ELSI-Brazil study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Fiber-based vegetarian score and the risk of incident dementia among elderly Chinese adults: a prospective cohort study.Frontiers in nutrition · 2026Article
- Rising burden of Alzheimer's disease and other dementias in Sierra Leone, 1990-2023: analysis of Global Burden of Disease 2023 estimates.BMJ neurology open · 2026Article
- The divergent effects of population aging: comparative analysis of the burden of Alzheimer's disease and other dementias in China and G20 countries, 1990-2050.American journal of translational research · 2026Article
- Global Burden of Alzheimer's Disease and Other Dementias during 1990-2021: A Global Burden of Disease and Risk Factors Study 2021-Based Study.Neuroepidemiology · 2026Article
- Immersive, Open-World Virtual Reality for Dementia Care: NeuroVRX Pilot Study.Journal of clinical medicine · 2025Article
- Large-scale proteomics project seeks cures for neurodegenerative diseases.Nature medicine · 2025Article
- The disease burden, risk factors and future predictions of Alzheimer's disease and other types of dementia in Asia from 1990 to 2021.The journal of prevention of Alzheimer's disease · 2025Article
- Gene Co-Expression Analysis Reveals Functional Differences Between Early- and Late-Onset Alzheimer's Disease.Current issues in molecular biology · 2025Article
- The Impact of Socioeconomic Factors on Cognitive Ability in Community-Dwelling Older Adults: Mediating Effect of Social Participation and Social Support.Healthcare (Basel, Switzerland) · 2025Article
- Prevalence, deaths and disability-adjusted life years due to Alzheimer's disease and other dementias in Middle East and North Africa, 1990-2021.Scientific reports · 2025Article
- Trends and Disparities in Alzheimer's Disease Mortality in the United States: The Impact of COVID-19.NeuroSci · 2025Article
- The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review.International journal of molecular sciences · 2025Review
- Global burden of Alzheimer's disease and other dementias (1990-2021): inequality, frontier, and decomposition analysis.Frontiers in aging neuroscience · 2025Article
- Microglial activation states and their implications for Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's Disease and Related Dementias (ADRD) affect millions of people worldwide, with mortality rates influenced by several risk factors and exhibiting significant heterogeneity across geographical regions. This study aimed to investigate the impact of risk factors on global ADRD mortality patterns from 1990 to 2021, utilizing clustering and modeling techniques. Data on ADRD mortality rates, cardiovascular disease, and diabetes prevalence were obtained for 204 countries from the GBD platform. Additional variables such as HDI, life expectancy, alcohol consumption, and tobacco use prevalence were sourced from the UNDP and WHO. All the data were extracted for men, women, and the overall population. Longitudinal k-means clustering and generalized estimating equations were applied for data analysis. The findings revealed that cardiovascular disease had significant positive effects of 1.84, 3.94, and 4.70 on men, women, and the overall ADRD mortality rates, respectively. Tobacco showed positive effects of 0.92, 0.13, and 0.39, while alcohol consumption had negative effects of - 0.59, - 9.92, and - 2.32, on men, women, and the overall ADRD mortality rates, respectively. The countries were classified into five distinct subgroups. Overall, cardiovascular disease and tobacco use were associated with increased ADRD mortality rates, while moderate alcohol consumption exhibited a protective effect. Notably, tobacco use showed a protective effect in cluster A, as did alcohol consumption in cluster B. The effects of risk factors on ADRD mortality rates varied among the clusters, highlighting the need for further investigation into the underlying causal factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.