Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Yuxi ZhouDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0001-5641-235X
Xin WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen YinDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan LiDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunlu GuoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-6073-5947
Chen ChenDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Johannes BoltzeSchool of Life Sciences, University of Warwick, Coventry, UK.
Arthur LieszInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Tim SparwasserInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Daxiang WenDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weifeng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peiying LiDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5721-9914
Funding
China Postdoctoral Science of Foundation 2022M712118German Research Foundation (DFG) under Germany's Excellence Strategy 390857198German Research Foundation (DFG) under Germany's Excellence Strategy 405358801Innovative Research Team of High-level Local Universities in Shanghai SHSMU-ZLCX20211602Institutional Clinical Research Program PYII20-03National Natural Science Foundation of China 81970478National Natural Science Foundation of China 81971096National Natural Science Foundation of China 81971223National Natural Science Foundation of China 82001381National Natural Science Foundation of China 82061130224National Natural Science Foundation of China 82101290National Natural Science Foundation of China 82101370National Natural Science Foundation of China 91957111National Natural Science Foundation of China U22A20295Shanghai Education Development Foundation and Shanghai Municipal Education Commission 20SG17Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation 20DZ2254200Shanghai Municipal Education Commission-Gaofeng Clinical Medical Grant Support 20181805Shanghai Municipal Science and Technology Committee 20XD1422400Shanghai Municipal Science and Technology Committee 23410711500Shanghai Shenkang Hospital Development Center SHDC12019102Sino-German Mobility Program M-0351Sino-German Mobility Program M-0671UK Academy of Medical Sciences NAF\R11\1010Vascular Dementia Research Foundation, the European Research Council ERC-StGs 802305
6 · The paper itself
Abstract
aimTo explore the regulatory mechanisms of microglia-mediated cytotoxic CD8
methodsAdult male C57BL/6 mice were subjected to ileocolic bowel resection (ICR) 24 h prior to permanent distant middle cerebral artery occlusion (dMCAO) to establish model PIS. White matter injury, functional outcomes, peripheral immune cell infiltration, and microglia phenotype were assessed up to 28 days after dMCAO using behavioral phenotyping, immunofluorescence staining, transmission electron microscopy, western blot, and FACS analysis.
resultsWe found surgery aggravated white matter injury and deteriorated sensorimotor deficits up to 28 days following PIS. The PIS mice exhibited significantly increased activation of peripheral and central CD8
conclusionSurgery exacerbates demyelination and worsens neurological function by promoting infiltration of CD8
Indexed as
CD8-Positive T-LymphocytesInfarction, Middle Cerebral ArteryMice, Inbred C57BLWhite MatterAnimalsDisease Models, AnimalLymphocyte ActivationMaleMiceMicrogliaReceptor-Interacting Protein Serine-Threonine KinasesStrokeReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseantigen presentingCD8+ T celldemyelinationperioperative strokeRIPK1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Perioperative stroke deteriorates white matter integrity by enhancing cytotoxic CD8 · full record | Socratic